Erik S Welf
Overview
Explore the profile of Erik S Welf including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1108
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Recent Articles
1.
Driscoll M, Welf E, Weems A, Sapoznik E, Zhou F, Murali V, et al.
Dev Cell
. 2024 Jun;
59(18):2414-2428.e8.
PMID: 38870943
In crowded microenvironments, migrating cells must find or make a path. Amoeboid cells are thought to find a path by deforming their bodies to squeeze through tight spaces. Yet, some...
2.
Davis J, Bravo Padros M, Conrado D, Ganguly S, Guan X, Hassan H, et al.
Clin Pharmacol Ther
. 2023 Dec;
115(3):422-439.
PMID: 38093583
Subcutaneous (s.c.) administration of monoclonal antibodies (mAbs) can reduce treatment burden for patients and healthcare systems compared with intravenous (i.v.) infusion through shorter administration times, made possible by convenient, patient-centric...
3.
Roudot P, Legant W, Zou Q, Dean K, Isogai T, Welf E, et al.
Cell Rep Methods
. 2023 Dec;
3(12):100655.
PMID: 38042149
We describe u-track3D, a software package that extends the versatile u-track framework established in 2D to address the specific challenges of 3D particle tracking. First, we present the performance of...
4.
Weems A, Welf E, Driscoll M, Zhou F, Mazloom-Farsibaf H, Chang B, et al.
Nature
. 2023 Mar;
615(7952):517-525.
PMID: 36859545
Most human cells require anchorage for survival. Cell-substrate adhesion activates diverse signalling pathways, without which cells undergo anoikis-a form of programmed cell death. Acquisition of anoikis resistance is a pivotal...
5.
Chang B, Manton J, Sapoznik E, Pohlkamp T, Terrones T, Welf E, et al.
Nat Methods
. 2021 Jun;
18(7):829-834.
PMID: 34183831
We introduce a cost-effective and easily implementable scan unit that converts any camera-based microscope with optical sectioning capability into a multi-angle projection imaging system. Projection imaging reduces data overhead and...
6.
Zaritsky A, Jamieson A, Welf E, Nevarez A, Cillay J, Eskiocak U, et al.
Cell Syst
. 2021 Jun;
12(7):733-747.e6.
PMID: 34077708
Deep learning has emerged as the technique of choice for identifying hidden patterns in cell imaging data but is often criticized as "black box." Here, we employ a generative neural...
7.
Murali V, Cobanoglu M, Welf E
Methods Mol Biol
. 2021 Mar;
2265:155-171.
PMID: 33704713
Researchers often aim to incorporate microenvironmental variables such as the dimensionality and composition of the extracellular matrix into their cell-based assays. A technical challenge created by introduction of these variables...
8.
Welf E, Miles C, Huh J, Sapoznik E, Chi J, Driscoll M, et al.
Dev Cell
. 2020 Dec;
55(6):723-736.e8.
PMID: 33308479
Despite the well-established role of actin polymerization as a driving mechanism for cell protrusion, upregulated actin polymerization alone does not initiate protrusions. Using a combination of theoretical modeling and quantitative...
9.
Sapoznik E, Chang B, Huh J, Ju R, Azarova E, Pohlkamp T, et al.
Elife
. 2020 Nov;
9.
PMID: 33179596
We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high...
10.
Driscoll M, Welf E, Jamieson A, Dean K, Isogai T, Fiolka R, et al.
Nat Methods
. 2019 Sep;
16(10):1037-1044.
PMID: 31501548
Rapid developments in live-cell three-dimensional (3D) microscopy enable imaging of cell morphology and signaling with unprecedented detail. However, tools to systematically measure and visualize the intricate relationships between intracellular signaling,...