Jason M Haugh
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Explore the profile of Jason M Haugh including associated specialties, affiliations and a list of published articles.
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73
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1426
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Recent Articles
1.
Jha A, Chandra A, Farahani P, Toettcher J, Haugh J, Waterman C
bioRxiv
. 2025 Jan;
PMID: 39803565
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the polarized bleb morphology...
2.
Nguyen K, Jameson C, Baldwin S, Nardini J, Smith R, Haugh J, et al.
Math Biosci
. 2024 Feb;
370:109158.
PMID: 38373479
Fibroblasts in a confluent monolayer are known to adopt elongated morphologies in which cells are oriented parallel to their neighbors. We collected and analyzed new microscopy movies to show that...
3.
Rahman S, Zhou W, Deiters A, Haugh J
Chembiochem
. 2023 Oct;
25(1):e202300551.
PMID: 37856284
Stress-activated signaling pathways orchestrate cellular behaviors and fates. Studying the precise role(s) of stress-activated protein kinases is challenging, because stress conditions induce adaptation and impose selection pressure. To meet this...
4.
Zhou W, Ryan A, Janosko C, Shoger K, Haugh J, Gottschalk R, et al.
RSC Chem Biol
. 2023 Oct;
4(10):765-773.
PMID: 37799579
Evolution has diversified the mammalian proteome by the generation of protein isoforms that originate from identical genes, , through alternative gene splicing or post-translational modifications, or very similar genes found...
5.
Appalabhotla R, Butler M, Bear J, Haugh J
Biophys J
. 2023 Aug;
122(18):3816-3829.
PMID: 37644720
To generate forces that drive migration of a eukaryotic cell, arrays of actin filaments (F-actin) are assembled at the cell's leading membrane edge. To maintain cell propulsion and respond to...
6.
Baldwin S, Haugh J
J Theor Biol
. 2023 Apr;
568:111506.
PMID: 37094713
Proper wound healing relies on invasion of fibroblasts via directed migration. While the related experimental and mathematical modeling literature has mainly focused on cell migration directed by soluble cues (chemotaxis),...
7.
Rahman S, Haugh J
Mol Biol Cell
. 2023 Mar;
34(6):ar60.
PMID: 36884295
The extracellular signal-regulated kinase (ERK) signaling pathway plays prominent roles in cell growth, proliferation, and differentiation. ERK signaling is dynamic, involving phosphorylation/dephosphorylation, nucleocytoplasmic shuttling, and interactions with scores of protein...
8.
Nosbisch J, Bear J, Haugh J
J Biol Chem
. 2022 Apr;
298(5):101886.
PMID: 35367415
Phospholipase C-γ1 (PLC-γ1) is a receptor-proximal enzyme that promotes signal transduction through PKC in mammalian cells. Because of the complexity of PLC-γ1 regulation, a two-state (inactive/active) model does not account...
9.
Chandra A, Butler M, Bear J, Haugh J
Biophys J
. 2021 Dec;
121(1):102-118.
PMID: 34861242
Orchestration of cell migration is essential for development, tissue regeneration, and the immune response. This dynamic process integrates adhesion, signaling, and cytoskeletal subprocesses across spatial and temporal scales. In mesenchymal...
10.
Baldwin S, Van Bruggen S, Koelbl J, Appalabhotla R, Bear J, Haugh J
Biomicrofluidics
. 2021 Jul;
15(4):044101.
PMID: 34290842
Microfluidics approaches have gained popularity in the field of directed cell migration, enabling control of the extracellular environment and integration with live-cell microscopy; however, technical hurdles remain. Among the challenges...