Erik Mullers
Overview
Explore the profile of Erik Mullers including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
593
Followers
0
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Recent Articles
1.
Rigal S, Casas B, Kanebratt K, Wennberg Huldt C, Magnusson L, Mullers E, et al.
Commun Biol
. 2024 Jul;
7(1):877.
PMID: 39025915
Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of...
2.
Fredin Haslum J, Lardeau C, Karlsson J, Turkki R, Leuchowius K, Smith K, et al.
Nat Commun
. 2024 Apr;
15(1):3470.
PMID: 38658534
Identifying active compounds for a target is a time- and resource-intensive task in early drug discovery. Accurate bioactivity prediction using morphological profiles could streamline the process, enabling smaller, more focused...
3.
Trapotsi M, Mouchet E, Williams G, Monteverde T, Juhani K, Turkki R, et al.
ACS Chem Biol
. 2022 Jul;
17(7):1733-1744.
PMID: 35793809
PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted protein degradation technology have been remarkable, with several molecules...
4.
Fredriksson J, Holdfeldt A, Martensson J, Bjorkman L, Moller T, Mullers E, et al.
Biochim Biophys Acta Mol Cell Res
. 2022 Mar;
1869(7):119262.
PMID: 35341806
In order to avoid a prolonged pro-inflammatory neutrophil response, signaling downstream of an agonist-activated G protein-coupled receptor (GPCR) has to be rapidly terminated. Among the family of GPCR kinases (GRKs)...
5.
Palano G, Foinquinos A, Mullers E
Front Physiol
. 2021 Jul;
12:697270.
PMID: 34305651
As a result of stress, injury, or aging, cardiac fibrosis is characterized by excessive deposition of extracellular matrix (ECM) components resulting in pathological remodeling, tissue stiffening, ventricular dilatation, and cardiac...
6.
Silva Cascales H, Burdova K, Middleton A, Kuzin V, Mullers E, Stoy H, et al.
Life Sci Alliance
. 2021 Jan;
4(3).
PMID: 33402344
Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2...
7.
Lafranchi L, Mullers E, Rutishauser D, Lindqvist A
Cells
. 2020 Sep;
9(9).
PMID: 32961751
Cells recovering from the G2/M DNA damage checkpoint rely more on Aurora A-PLK1 signaling than cells progressing through an unperturbed G2 phase, but the reason for this discrepancy is not...
8.
Drowley L, McPheat J, Nordqvist A, Peel S, Karlsson U, Martinsson S, et al.
Stem Cells Transl Med
. 2019 Sep;
9(1):47-60.
PMID: 31508905
Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools...
9.
Silva Cascales H, Mullers E, Lindqvist A
Aging (Albany NY)
. 2017 Nov;
9(10):2022-2023.
PMID: 29084933
No abstract available.
10.
Jaiswal H, Benada J, Mullers E, Akopyan K, Burdova K, Koolmeister T, et al.
EMBO J
. 2017 Jun;
36(14):2161-2176.
PMID: 28607002
After DNA damage, the cell cycle is arrested to avoid propagation of mutations. Arrest in G2 phase is initiated by ATM-/ATR-dependent signaling that inhibits mitosis-promoting kinases such as Plk1. At...