Helena Silva Cascales
Overview
Explore the profile of Helena Silva Cascales including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
242
Followers
0
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Recent Articles
1.
Li Q, Hagberg C, Silva Cascales H, Lang S, Hyvonen M, Salehzadeh F, et al.
Nat Med
. 2021 Oct;
27(11):1941-1953.
PMID: 34608330
Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both...
2.
Silva Cascales H, Burdova K, Middleton A, Kuzin V, Mullers E, Stoy H, et al.
Life Sci Alliance
. 2021 Jan;
4(3).
PMID: 33402344
Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2...
3.
Silva Cascales H, Mullers E, Lindqvist A
Aging (Albany NY)
. 2017 Nov;
9(10):2022-2023.
PMID: 29084933
No abstract available.
4.
Mullers E, Silva Cascales H, Burdova K, Macurek L, Lindqvist A
Aging Cell
. 2017 Mar;
16(3):575-584.
PMID: 28345297
In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation...
5.
Braune E, Tsoi Y, Phoon Y, Landor S, Silva Cascales H, Ramskold D, et al.
Stem Cell Reports
. 2016 Apr;
6(5):643-651.
PMID: 27066863
Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development;...
6.
Mullers E, Silva Cascales H, Jaiswal H, Saurin A, Lindqvist A
Cell Cycle
. 2014 Dec;
13(17):2733-43.
PMID: 25486360
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells...
7.
Akopyan K, Silva Cascales H, Hukasova E, Saurin A, Mullers E, Jaiswal H, et al.
Mol Cell
. 2014 Mar;
53(5):843-53.
PMID: 24582498
During the cell cycle, DNA duplication in S phase must occur before a cell divides in mitosis. In the intervening G2 phase, mitotic inducers accumulate, which eventually leads to a...
8.
Hukasova E, Silva Cascales H, Kumar S, Lindqvist A
J Vis Exp
. 2012 Feb;
(59):e3410.
PMID: 22314640
Förster resonance energy transfer (FRET)-based reporters(1) allow the assessment of endogenous kinase and phosphatase activities in living cells. Such probes typically consist of variants of CFP and YFP, intervened by...