Richard P Zaniewski
Overview
Explore the profile of Richard P Zaniewski including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
178
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Starr J, Brown M, Aschenbrenner L, Caspers N, Che Y, Gerstenberger B, et al.
J Med Chem
. 2014 Apr;
57(9):3845-55.
PMID: 24694215
Multidrug-resistant Gram-negative pathogens are an emerging threat to human health, and addressing this challenge will require development of new antibacterial agents. This can be achieved through an improved molecular understanding...
2.
Brown M, Mitton-Fry M, Arcari J, Barham R, Casavant J, Gerstenberger B, et al.
J Med Chem
. 2013 Jun;
56(13):5541-52.
PMID: 23755848
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella...
3.
Mitton-Fry M, Brickner S, Hamel J, Brennan L, Casavant J, Chen M, et al.
Bioorg Med Chem Lett
. 2013 Apr;
23(10):2955-61.
PMID: 23566517
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were...
4.
Papp-Wallace K, Senkfor B, Gatta J, Chai W, Taracila M, Shanmugasundaram V, et al.
Antimicrob Agents Chemother
. 2012 Aug;
56(11):5687-92.
PMID: 22908165
Acinetobacter baumannii is an increasingly problematic pathogen in United States hospitals. Antibiotics that can treat A. baumannii are becoming more limited. Little is known about the contributions of penicillin binding...
5.
Han S, Caspers N, Zaniewski R, Lacey B, Tomaras A, Feng X, et al.
J Am Chem Soc
. 2011 Nov;
133(50):20536-45.
PMID: 22050378
Multi-drug-resistant forms of the Gram-negative pathogen Acinetobacter baumannii are an emerging threat to human health and further complicate the general problem of treating serious bacterial infections. Meeting this challenge requires...
6.
Han S, Zaniewski R, Marr E, Lacey B, Tomaras A, Evdokimov A, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
107(51):22002-7.
PMID: 21135211
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes nosocomial infections for which there are limited treatment options. Penicillin-binding protein PBP3, a key therapeutic target, is an essential enzyme responsible...
7.
Le P, Brickner S, Wade S, Brighty K, Monahan R, Stone G, et al.
Bioorg Med Chem Lett
. 2010 Dec;
21(1):276-9.
PMID: 21115249
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the...
8.
Simons S, McLellan T, Aeed P, Zaniewski R, Desbonnet C, Wondrack L, et al.
Anal Biochem
. 2009 Aug;
395(1):77-85.
PMID: 19646947
We have developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans that exploits its association with FLAG-tagged 30S subunits. Thus, capture is indirect so that no modification...
9.
Stone G, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, et al.
Antimicrob Agents Chemother
. 2008 Apr;
52(7):2663-6.
PMID: 18426902
We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its...