Eric M Phizicky
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Explore the profile of Eric M Phizicky including associated specialties, affiliations and a list of published articles.
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72
Citations
4356
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Recent Articles
11.
PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly
Shaheen R, Tasak M, Maddirevula S, Abdel-Salam G, Sayed I, AlAzami A, et al.
Hum Genet
. 2019 Feb;
138(3):231-239.
PMID: 30778726
Pseudouridylation is the most common post-transcriptional modification, wherein uridine is isomerized into 5-ribosyluracil (pseudouridine, Ψ). The resulting increase in base stacking and creation of additional hydrogen bonds are thought to...
12.
Han L, Phizicky E
RNA
. 2018 Jul;
24(10):1277-1284.
PMID: 30026310
The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function. While most modifications are introduced to tRNA independently, several sets of modifications are found to be interconnected...
13.
Zimmerman S, Kon Y, Hauke A, Ruiz B, Fields S, Phizicky E
Nucleic Acids Res
. 2018 Jul;
46(15):7831-7843.
PMID: 30007351
To develop a system for conditional amino acid misincorporation, we engineered tRNAs in the yeast Saccharomyces cerevisiae to be substrates of the rapid tRNA decay (RTD) pathway, such that they...
14.
Han L, Guy M, Kon Y, Phizicky E
PLoS Genet
. 2018 Mar;
14(3):e1007288.
PMID: 29596413
Modification defects in the tRNA anticodon loop often impair yeast growth and cause human disease. In the budding yeast Saccharomyces cerevisiae and the phylogenetically distant fission yeast Schizosaccharomyces pombe, trm7Δ...
15.
Payea M, Sloma M, Kon Y, Young D, Guy M, Zhang X, et al.
RNA
. 2017 Dec;
24(3):410-422.
PMID: 29259051
Microorganisms have universally adapted their RNAs and proteins to survive at a broad range of temperatures and growth conditions. However, for RNAs, there is little quantitative understanding of the effects...
16.
Hrabeta-Robinson E, Marcus E, Cozen A, Phizicky E, Lowe T
Methods Mol Biol
. 2017 Mar;
1562:231-243.
PMID: 28349464
N -methyladenosine (mA), N -methylcytidine (mC), and N -methylguanosine (mG) are common in transfer RNA (tRNA) and tRNA-derived fragments. These modifications alter Watson-Crick base-pairing, and cause pauses or stops during...
17.
Han L, Marcus E, DSilva S, Phizicky E
RNA
. 2016 Dec;
23(3):406-419.
PMID: 28003514
The 3-methylcytidine (mC) modification is ubiquitous in eukaryotic tRNA, widely found at C in the anticodon loop of tRNA, tRNA, and some tRNA species, as well as in the variable...
18.
Patra B, Kon Y, Yadav G, Sevold A, Frumkin J, Vallabhajosyula R, et al.
Nucleic Acids Res
. 2016 Dec;
45(1):255-270.
PMID: 27899637
Genomic robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of genomic robustness in budding yeast by genome...
19.
Shaheen R, Han L, Faqeih E, Ewida N, Alobeid E, Phizicky E, et al.
Hum Genet
. 2016 Apr;
135(7):707-13.
PMID: 27055666
Intellectual disability is a common and highly heterogeneous disorder etiologically. In a multiplex consanguineous family, we applied autozygosity mapping and exome sequencing and identified a novel homozygous truncating mutation in...
20.
Shaheen R, Abdel-Salam G, Guy M, Alomar R, Abdel-Hamid M, Afifi H, et al.
Genome Biol
. 2015 Sep;
16:210.
PMID: 26416026
Background: Primordial dwarfism is a state of extreme prenatal and postnatal growth deficiency, and is characterized by marked clinical and genetic heterogeneity. Results: Two presumably unrelated consanguineous families presented with...