Eric M Phizicky
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Explore the profile of Eric M Phizicky including associated specialties, affiliations and a list of published articles.
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72
Citations
4356
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Recent Articles
21.
Guy M, Shaw M, Weiner C, Hobson L, Stark Z, Rose K, et al.
Hum Mutat
. 2015 Aug;
36(12):1176-87.
PMID: 26310293
tRNA modifications are crucial for efficient and accurate protein synthesis, and modification defects are frequently associated with disease. Yeast trm7Δ mutants grow poorly due to lack of 2'-O-methylated C32 (Cm32...
22.
Payea M, Guy M, Phizicky E
Methods Enzymol
. 2015 Aug;
560:1-17.
PMID: 26253963
The rapid tRNA decay (RTD) pathway is a tRNA quality control pathway known to degrade several specific hypomodified or destabilized tRNAs in the yeast Saccharomyces cerevisiae. In this chapter, we...
23.
Cozen A, Quartley E, Holmes A, Hrabeta-Robinson E, Phizicky E, Lowe T
Nat Methods
. 2015 Aug;
12(9):879-84.
PMID: 26237225
High-throughput RNA sequencing has accelerated discovery of the complex regulatory roles of small RNAs, but RNAs containing modified nucleosides may escape detection when those modifications interfere with reverse transcription during...
24.
25.
Guy M, Phizicky E
RNA Biol
. 2015 Jan;
11(12):1608-18.
PMID: 25625329
tRNA modifications are crucial for efficient and accurate protein translation, with defects often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast Saccharomyces cerevisiae that are formed...
26.
Pop C, Rouskin S, Ingolia N, Han L, Phizicky E, Weissman J, et al.
Mol Syst Biol
. 2014 Dec;
10:770.
PMID: 25538139
Ribosome profiling data report on the distribution of translating ribosomes, at steady-state, with codon-level resolution. We present a robust method to extract codon translation rates and protein synthesis rates from...
27.
Han L, Kon Y, Phizicky E
RNA
. 2014 Dec;
21(2):188-201.
PMID: 25505024
The numerous modifications of tRNA play central roles in controlling tRNA structure and translation. Modifications in and around the anticodon loop often have critical roles in decoding mRNA and in...
28.
Guy M, Phizicky E
RNA
. 2014 Nov;
21(1):61-74.
PMID: 25404562
Post-transcriptional tRNA modifications are critical for efficient and accurate translation, and have multiple different roles. Lack of modifications often leads to different biological consequences in different organisms, and in humans...
29.
Zhang X, Walker R, Phizicky E, Mathews D
J Chem Theory Comput
. 2014 Aug;
10(8):3473-3483.
PMID: 25136272
Modified nucleotides are prevalent in tRNA. Experimental studies reveal that these covalent modifications play an important role in tuning tRNA function. In this study, molecular dynamics (MD) simulations were used...
30.
Guy M, Young D, Payea M, Zhang X, Kon Y, Dean K, et al.
Genes Dev
. 2014 Aug;
28(15):1721-32.
PMID: 25085423
Sequence variation in tRNA genes influences the structure, modification, and stability of tRNA; affects translation fidelity; impacts the activity of numerous isodecoders in metazoans; and leads to human diseases. To...