How Degrading! Trapped Translation Factors Get Trashed
Overview
Overview
Journal
Cell Rep
Publisher
Cell Press
Specialties
Biology
Cell Biology
Molecular Biology
Cell Biology
Molecular Biology
Date
2023 Nov 1
PMID
37910507
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Using small molecules that trap translation factors within translating ribosomes, Gurzeler et al. and Oltion et al. identify a new branch of the ribosome-associated quality-control (RQC) pathway. This mode of translation regulation expands the number of mechanistically distinct RQC pathways.
References
1.
Yip M, Shao S
. Detecting and Rescuing Stalled Ribosomes. Trends Biochem Sci. 2021; 46(9):731-743.
PMC: 8487456.
DOI: 10.1016/j.tibs.2021.03.008.
View
2.
Juette M, Carelli J, Rundlet E, Brown A, Shao S, Ferguson A
. Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes. Elife. 2022; 11.
PMC: 9584604.
DOI: 10.7554/eLife.81608.
View
3.
Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde R
. ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol Cell. 2018; 72(3):469-481.e7.
PMC: 6224477.
DOI: 10.1016/j.molcel.2018.08.037.
View
4.
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett E
. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017; 65(4):751-760.e4.
PMC: 5321136.
DOI: 10.1016/j.molcel.2016.12.026.
View
5.
Gurzeler L, Link M, Ibig Y, Schmidt I, Galuba O, Schoenbett J
. Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control. Cell Rep. 2023; 42(9):113056.
DOI: 10.1016/j.celrep.2023.113056.
View