Eric D Labonte
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Explore the profile of Eric D Labonte including associated specialties, affiliations and a list of published articles.
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11
Citations
340
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Recent Articles
1.
Jacobs J, Leadbetter M, Bell N, Koo-McCoy S, Carreras C, He L, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1043-1051.
PMID: 35859876
We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na/H exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts...
2.
Johansson S, Leonsson-Zachrisson M, Knutsson M, Spencer A, Labonte E, Deshpande D, et al.
Clin Pharmacol Drug Dev
. 2016 Sep;
6(5):448-456.
PMID: 27654985
Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption...
3.
Labonte E, Carreras C, Leadbetter M, Kozuka K, Kohler J, Koo-McCoy S, et al.
J Am Soc Nephrol
. 2014 Nov;
26(5):1138-49.
PMID: 25404658
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and cardiovascular mortality. Tenapanor, a...
4.
Spencer A, Labonte E, Rosenbaum D, Plato C, Carreras C, Leadbetter M, et al.
Sci Transl Med
. 2014 Mar;
6(227):227ra36.
PMID: 24622516
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which...
5.
Labonte E, Pfluger P, Cash J, Kuhel D, Roja J, Magness D, et al.
FASEB J
. 2010 Mar;
24(7):2516-24.
PMID: 20215528
Decrease in fat catabolic rate on consuming a high-fat diet contributes to diet-induced obesity. This study used group 1B phospholipase A(2) (Pla2g1b)-deficient mice, which are resistant to hyperglycemia, to test...
6.
Labonte E, Camarota L, Rojas J, Jandacek R, Gilham D, Davies J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2008 Aug;
295(4):G776-83.
PMID: 18718999
The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism of other nutrients have been only minimally investigated. Thus...
7.
Hui D, Labonte E, Howles P
Am J Physiol Gastrointest Liver Physiol
. 2008 Feb;
294(4):G839-43.
PMID: 18276831
Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I,...
8.
Gilham D, Labonte E, Rojas J, Jandacek R, Howles P, Hui D
J Biol Chem
. 2007 Jul;
282(34):24642-9.
PMID: 17604277
This study evaluated the contributions of carboxyl ester lipase (CEL) and pancreatic triglyceride lipase (PTL) in lipid nutrient absorption. Results showed PTL deficiency has minimal effect on triacylglycerol (TAG) absorption...
9.
Labonte E, Howles P, Granholm N, Rojas J, Davies J, Ioannou Y, et al.
Biochim Biophys Acta
. 2007 Apr;
1771(9):1132-9.
PMID: 17442616
Recent studies have documented the importance of Niemann-Pick C1-like 1 protein (NPC1L1), a putative physiological target of the drug ezetimibe, in mediating intestinal cholesterol absorption. However, whether NPC1L1 is the...
10.
Labonte E, Kirby R, Schildmeyer N, Cannon A, Huggins K, Hui D
Diabetes
. 2006 Mar;
55(4):935-41.
PMID: 16567514
Postprandial hyperglycemia is an early indicator of abnormality in glucose metabolism leading to type 2 diabetes. However, mechanisms that contribute to postprandial hyperglycemia have not been identified. This study showed...