Andrew G Spencer
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Explore the profile of Andrew G Spencer including associated specialties, affiliations and a list of published articles.
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10
Citations
291
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Recent Articles
1.
Gulbins A, Horstmann M, Daser A, Flogel U, Oeverhaus M, Bechrakis N, et al.
Front Endocrinol (Lausanne)
. 2023 Jul;
14:1211473.
PMID: 37435490
Introduction: Graves' disease (GD) is an autoimmune disorder caused by autoantibodies against the thyroid stimulating hormone receptor (TSHR) leading to overstimulation of the thyroid gland. Thyroid eye disease (TED) is...
2.
Jacobs J, Leadbetter M, Bell N, Koo-McCoy S, Carreras C, He L, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1043-1051.
PMID: 35859876
We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na/H exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts...
3.
Chen T, Reich N, Bell N, Finn P, Rodriguez D, Kohler J, et al.
J Med Chem
. 2018 Aug;
61(17):7589-7613.
PMID: 30141927
Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) is one of the major effectors in...
4.
Johansson S, Leonsson-Zachrisson M, Knutsson M, Spencer A, Labonte E, Deshpande D, et al.
Clin Pharmacol Drug Dev
. 2016 Sep;
6(5):448-456.
PMID: 27654985
Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption...
5.
Spencer A, Greasley P
Curr Opin Nephrol Hypertens
. 2015 Jul;
24(5):410-6.
PMID: 26197202
Purpose Of Review: Impaired sodium excretion in patients with chronic kidney disease (CKD) can drive fluid overload and hypertension and accelerate CKD progression. Diuretics reduce fluid overload but require residual...
6.
Labonte E, Carreras C, Leadbetter M, Kozuka K, Kohler J, Koo-McCoy S, et al.
J Am Soc Nephrol
. 2014 Nov;
26(5):1138-49.
PMID: 25404658
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and cardiovascular mortality. Tenapanor, a...
7.
Spencer A, Labonte E, Rosenbaum D, Plato C, Carreras C, Leadbetter M, et al.
Sci Transl Med
. 2014 Mar;
6(227):227ra36.
PMID: 24622516
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which...
8.
Siegel M, Garber M, Spencer A, Botwick W, Kumar P, Williams R, et al.
Dig Dis Sci
. 2011 Sep;
57(2):440-50.
PMID: 21948339
Background: Celiac disease is the most common hereditary autoimmune disease in humans. The only treatment option for non-refractory celiac disease patients is adherence to a strict life-long gluten-free diet, which...
9.
De Souza A, Dai X, Spencer A, Reppen T, Menzie A, Roesch P, et al.
Nucleic Acids Res
. 2006 Sep;
34(16):4486-94.
PMID: 16945951
RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be...
10.
Mowery P, Yang Z, Gordon E, Dwir O, Spencer A, Alon R, et al.
Chem Biol
. 2004 May;
11(5):725-32.
PMID: 15157883
L-selectin is a leukocyte cell-surface protein that facilitates the rolling of leukocytes along the endothelium, a process that leads to leukocyte migration to a site of infection. Preventing L-selectin-mediated rolling...