En-Ching Luo
Overview
Explore the profile of En-Ching Luo including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
700
Followers
0
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Recent Articles
1.
Schmok J, Jain M, Street L, Tankka A, Schafer D, Her H, et al.
Nat Biotechnol
. 2024 Feb;
42(9):1467.
PMID: 38418649
No abstract available.
2.
Schmok J, Jain M, Street L, Tankka A, Schafer D, Her H, et al.
Nat Biotechnol
. 2024 Jan;
42(9):1429-1441.
PMID: 38168984
RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform expression and cellular survival. To identify RBPs that directly drive alternative exon inclusion, we developed tethered function luciferase-based splicing reporters...
3.
Antal C, Oh T, Aigner S, Luo E, Yee B, Campos T, et al.
Nat Commun
. 2023 Sep;
14(1):5195.
PMID: 37673892
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here...
4.
Kameda-Smith M, Zhu H, Luo E, Suk Y, Xella A, Yee B, et al.
Nat Commun
. 2023 Jan;
14(1):136.
PMID: 36627300
No abstract available.
5.
Kameda-Smith M, Zhu H, Luo E, Suk Y, Xella A, Yee B, et al.
Nat Commun
. 2022 Dec;
13(1):7506.
PMID: 36473869
Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in...
6.
Xiang J, Mueller J, Luo E, Yee B, Schafer D, Schmok J, et al.
Res Sq
. 2022 Mar;
PMID: 35313591
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced...
7.
Xiang J, Mueller J, Luo E, Yee B, Schafer D, Schmok J, et al.
bioRxiv
. 2022 Mar;
PMID: 35233578
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced...
8.
Van Nostrand J, Hellberg K, Luo E, Van Nostrand E, Dayn A, Yu J, et al.
Genes Dev
. 2020 Sep;
34(19-20):1330-1344.
PMID: 32912901
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the...
9.
Luo E, Nathanson J, Tan F, Schwartz J, Schmok J, Shankar A, et al.
Nat Struct Mol Biol
. 2020 Aug;
27(10):989-1000.
PMID: 32807991
The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource...
10.
Coyne A, Zaepfel B, Hayes L, Fitchman B, Salzberg Y, Luo E, et al.
Neuron
. 2020 Jul;
107(6):1124-1140.e11.
PMID: 32673563
Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and accumulations of specific nuclear-pore-complex-associated proteins have been reported in multiple neurodegenerative diseases, including C9orf72 Amyotrophic Lateral Sclerosis and Frontotemporal...