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Emilia Lecuona

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Articles 55
Citations 1319
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Recent Articles
1.
Liu X, Ren Z, Tan C, Nunez-Santana F, Kelly M, Yan Y, et al.
J Clin Invest . 2024 Nov; 134(22). PMID: 39545417
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for...
2.
Yang W, Lecuona E, Wu Q, Liu X, Sun H, Alam H, et al.
Front Transplant . 2024 Jul; 2:1237671. PMID: 38993924
Lung transplantation is a life-saving treatment for both chronic end-stage lung diseases and acute respiratory distress syndrome, including those caused by infectious agents like COVID-19. Despite its increasing utilization, outcomes...
3.
Yang W, Cerier E, Nunez-Santana F, Wu Q, Yan Y, Kurihara C, et al.
J Clin Invest . 2022 Oct; 132(20). PMID: 36250462
Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung...
4.
Querrey M, Chiu S, Lecuona E, Wu Q, Sun H, Anderson M, et al.
J Clin Invest . 2022 Jul; 132(14). PMID: 35838047
Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction. The mechanistic...
5.
Li W, Terada Y, Tyurina Y, Tyurin V, Bery A, Gauthier J, et al.
Proc Natl Acad Sci U S A . 2022 Mar; 119(10):e2111537119. PMID: 35238643
Ischemia reperfusion injury represents a common pathological condition that is triggered by the release of endogenous ligands. While neutrophils are known to play a critical role in its pathogenesis, the...
6.
Yang W, Chiu S, Querrey M, Liu X, Wu Q, Cerier E, et al.
Am J Respir Cell Mol Biol . 2021 Mar; 64(3):391-394. PMID: 33646091
No abstract available.
7.
Kurihara C, Lecuona E, Wu Q, Yang W, Nunez-Santana F, Akbarpour M, et al.
JCI Insight . 2021 Feb; 6(6). PMID: 33621212
Primary graft dysfunction (PGD) is the predominant cause of early graft loss following lung transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical monocytes (NCM) initiate neutrophil recruitment. Simultaneously, host-origin...
8.
Ceco E, Celli D, Weinberg S, Shigemura M, Welch L, Volpe L, et al.
Front Physiol . 2021 Feb; 11:630910. PMID: 33551852
Muscle dysfunction often occurs in patients with chronic obstructive pulmonary diseases (COPD) and affects ventilatory and non-ventilatory skeletal muscles. We have previously reported that hypercapnia (elevated CO levels) causes muscle...
9.
Runyan C, Welch L, Lecuona E, Shigemura M, Amarelle L, Abdala-Valencia H, et al.
Aging Cell . 2020 Jul; 19(9):e13180. PMID: 32720752
Skeletal muscle dysfunction in survivors of pneumonia disproportionately affects older individuals in whom it causes substantial morbidity. We found that skeletal muscle recovery was impaired in old compared with young...
10.
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, et al.
J Clin Invest . 2020 Jul; 130(8):4456-4469. PMID: 32692317
Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists...