Elizabeth H Kellogg
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Explore the profile of Elizabeth H Kellogg including associated specialties, affiliations and a list of published articles.
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24
Citations
1641
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Recent Articles
1.
Schargel R, Qayyum M, Tanwar A, Kalathur R, Kellogg E
Nat Struct Mol Biol
. 2024 Oct;
32(2):243-246.
PMID: 39354233
RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are called Fanzors. They are classified into two clades, Fanzor1 and Fanzor2. Here we...
2.
Hwang Y, Cornman A, Kellogg E, Ovchinnikov S, Girguis P
Nat Commun
. 2024 Apr;
15(1):2880.
PMID: 38570504
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function...
3.
George J, Acree C, Park J, Kong M, Wiegand T, Pignot Y, et al.
Science
. 2023 Nov;
382(6672):eadj8543.
PMID: 37972161
CRISPR-associated transposases (CASTs) repurpose nuclease-deficient CRISPR effectors to catalyze RNA-guided transposition of large genetic payloads. Type V-K CASTs offer potential technology advantages but lack accuracy, and the molecular basis for...
4.
George J, Acree C, Park J, Kong M, Wiegand T, Pignot Y, et al.
bioRxiv
. 2023 Jul;
PMID: 37503092
Unlike canonical CRISPR-Cas systems that rely on RNA-guided nucleases for target cleavage, CRISPR-associated transposases (CASTs) repurpose nuclease-deficient CRISPR effectors to facilitate RNA-guided transposition of large genetic payloads. Type V-K CASTs...
5.
Park J, Petassi M, Hsieh S, Mehrotra E, Schuler G, Budhathoki J, et al.
Mol Cell
. 2023 Jun;
83(11):1827-1838.e6.
PMID: 37267904
CRISPR-associated transposons (CASTs) are natural RNA-directed transposition systems. We demonstrate that transposon protein TniQ plays a central role in promoting R-loop formation by RNA-guided DNA-targeting modules. TniQ residues, proximal to...
6.
VanderWal A, Park J, Polevoda B, Nicosia J, Molina Vargas A, Kellogg E, et al.
Science
. 2023 Apr;
380(6643):410-415.
PMID: 37104586
Type VI CRISPR-Cas systems use RNA-guided ribonuclease (RNase) Cas13 to defend bacteria against viruses, and some of these systems encode putative membrane proteins that have unclear roles in Cas13-mediated defense....
7.
Park J, Tsai A, Rizo A, Truong V, Wellner T, Schargel R, et al.
Nature
. 2022 Nov;
613(7945):775-782.
PMID: 36442503
CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism. CAST elements contain multiple conserved proteins: a CRISPR effector (Cas12k or Cascade), a...
8.
Kellogg E, Gootenberg J, Abudayyeh O, Wong A, Dahlman J, Lapinaite A, et al.
Cell Syst
. 2022 Aug;
13(8):589-593.
PMID: 35981511
No abstract available.
9.
Park J, Tsai A, Chen T, Peters J, Kellogg E
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2202590119.
PMID: 35914146
CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided DNA integration. Although structural data are known for nearly all core transposition components, the transposase component, TnsB, remains uncharacterized....
10.
Jack A, Kim Y, Strom A, Lee D, Williams B, Schaub J, et al.
Dev Cell
. 2022 Jan;
57(2):277-290.e9.
PMID: 35077681
Telomeres form unique nuclear compartments that prevent degradation and fusion of chromosome ends by recruiting shelterin proteins and regulating access of DNA damage repair factors. To understand how these dynamic...