Samuel H Sternberg
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Explore the profile of Samuel H Sternberg including associated specialties, affiliations and a list of published articles.
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53
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5642
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Recent Articles
1.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg S
Nat Microbiol
. 2025 Jan;
10(1):20-27.
PMID: 39747689
Transposase genes are ubiquitous in all domains of life and provide a rich reservoir for the evolution of novel protein functions. Here we report deep evolutionary links between bacterial IS110-family...
2.
Stearns K, Lampe G, Hanan R, Marcink T, Niewiesk S, Sternberg S, et al.
mBio
. 2024 Oct;
15(11):e0232724.
PMID: 39382296
Importance: Enveloped viruses cause a wide range of diseases in humans. At the first step of infection, these viruses must fuse their envelope with a cell membrane to initiate infection....
3.
Lampe G, Liang A, Zhang D, Fernandez I, Sternberg S
bioRxiv
. 2024 Sep;
PMID: 39345383
Conventional genome editing tools rely on DNA double-strand breaks (DSBs) and host recombination proteins to achieve large insertions, resulting in a heterogeneous mixture of undesirable editing outcomes. We recently leveraged...
4.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
Science
. 2024 Aug;
386(6717):eadq0876.
PMID: 39116258
Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown. We show that DRT2...
5.
Zedaveinyte R, Meers C, Le H, Mortman E, Tang S, Lampe G, et al.
Science
. 2024 Jul;
385(6705):eadm8189.
PMID: 38991068
TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life. IS605-family TnpB homologs function as programmable RNA-guided homing endonucleases in bacteria, driving transposon maintenance...
6.
Vaysset H, Meers C, Cury J, Bernheim A, Sternberg S
bioRxiv
. 2024 Jul;
PMID: 38948817
Transposase genes are ubiquitous in all domains of life and provide a rich reservoir for the evolution of novel protein functions. Here we report deep evolutionary links between bacterial IS110...
7.
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
Nature
. 2024 Jun;
631(8020):439-448.
PMID: 38926585
Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. These widespread gene families were repeatedly domesticated over...
8.
Tang S, Conte V, Zhang D, Zedaveinyte R, Lampe G, Wiegand T, et al.
bioRxiv
. 2024 May;
PMID: 38766058
Bacteria defend themselves from viral infection using diverse immune systems, many of which sense and target foreign nucleic acids. Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this...
9.
Gelsinger D, Vo P, Klompe S, Ronda C, Wang H, Sternberg S
Nat Protoc
. 2024 Jan;
19(3):752-790.
PMID: 38216671
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated transposases have the potential to transform the technology landscape for kilobase-scale genome engineering, by virtue of their ability to integrate large genetic payloads...
10.
Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases
Wiegand T, Hoffmann F, Walker M, Tang S, Richard E, Le H, et al.
bioRxiv
. 2023 Dec;
PMID: 38076855
Transposon-encoded genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination. This widespread gene family was repeatedly domesticated over evolutionary timescales, leading...