Amy Wei-Lun Tsai
Overview
Explore the profile of Amy Wei-Lun Tsai including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
86
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Recent Articles
1.
Park J, Tsai A, Rizo A, Truong V, Wellner T, Schargel R, et al.
Nature
. 2022 Nov;
613(7945):775-782.
PMID: 36442503
CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism. CAST elements contain multiple conserved proteins: a CRISPR effector (Cas12k or Cascade), a...
2.
Park J, Tsai A, Chen T, Peters J, Kellogg E
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2202590119.
PMID: 35914146
CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided DNA integration. Although structural data are known for nearly all core transposition components, the transposase component, TnsB, remains uncharacterized....
3.
Paul E, Lin K, Gamble N, Tsai A, Swan S, Yang Y, et al.
Biophys Chem
. 2021 Dec;
281:106740.
PMID: 34923394
Translation initiation in eukaryotes requires multiple eukaryotic translation initiation factors (eIFs) and involves continuous remodeling of the ribosomal preinitiation complex (PIC). The GTPase eIF2 brings the initiator Met-tRNA to the...
4.
Park J, Tsai A, Mehrotra E, Petassi M, Hsieh S, Ke A, et al.
Science
. 2021 Aug;
373(6556):768-774.
PMID: 34385391
CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA cargo in one orientation at a fixed distance from a programmable target sequence. We used cryo-electron microscopy (cryo-EM) to...