Elena Brin
Overview
Explore the profile of Elena Brin including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
86
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0
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Recent Articles
1.
Brin E, Wu K, Dagostino E, Meng-Chiang Kuo M, He Y, Shia W, et al.
Oncotarget
. 2019 Jan;
9(97):36914-36928.
PMID: 30651925
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and...
2.
Richards T, Brin E
Oncotarget
. 2018 Aug;
9(56):30814-30820.
PMID: 30112109
Indoleamine 2,3-dioxygenase 1 (IDO1) is a new immune-oncology target and its inhibitors have shown promise in the clinic especially in combination with other immune-stimulating agents. Here we describe two robust...
3.
Brin E, Wu K, Lu H, He Y, Dai Z, He W
Oncotarget
. 2017 Sep;
8(35):58948-58963.
PMID: 28938609
PEGylated arginine deiminase (ADI-PEG 20) is being investigated in clinical studies in arginine auxotrophic cancers and is well-tolerated. The anti-tumor properties of ADI-PEG 20 have been extensively investigated - ADI-PEG...
4.
Pande K, Ueda R, Machemer T, Sathe M, Tsai V, Brin E, et al.
Mol Ther
. 2009 Jan;
17(3):508-15.
PMID: 19127252
Intravascular delivery (1.5 x 10(9) particles and higher) of recombinant adenovirus (rAd) induces myeloid cell mediated, self-limiting hemodynamic responses in normal mice. However, we observed anaphylactoid-type reactions and exacerbated hemodynamic...
5.
Claassen G, Brin E, Crogan-Grundy C, Vaillancourt M, Zhang H, Xiong Cai S, et al.
Cancer Lett
. 2008 Nov;
274(2):243-9.
PMID: 19008038
Oncogene addiction due to Myc deregulation has been identified in a variety of tumor types. In order to identify pharmacological agents that cause selective apoptosis in tumors with deregulated Myc...
6.
Machemer T, Engler H, Tsai V, Lee S, Cannon-Carlson S, Voloch M, et al.
Mol Ther
. 2005 Jul;
12(2):254-63.
PMID: 16043097
Intravascular administration of recombinant adenovirus (rAd) in cancer patients has been well tolerated. However, dose-limiting hemodynamic responses associated with suppression of cardiac output have been observed at doses of 7.5...
7.
Brin E, Leis J
J Biol Chem
. 2002 Mar;
277(21):18357-64.
PMID: 11897790
Successful integration of viral genome into a host chromosome depends on interaction between viral integrase and its recognition sequences. We have used a reconstituted concerted human immunodeficiency virus, type 1...
8.
Brin E, Leis J
J Biol Chem
. 2002 Jan;
277(13):10938-48.
PMID: 11788585
We have reconstituted concerted human immunodeficiency virus type 1 (HIV-1) integration with specially designed mini-donor DNA, a supercoiled plasmid acceptor, purified bacterial-derived HIV-1 integrase (IN), and host HMG-I(Y) protein (Hindmarsh,...