Jonathan Leis
Overview
Explore the profile of Jonathan Leis including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
485
Followers
0
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Recent Articles
1.
Leis J, Luan C, Audia J, Dunne S, Heath C
J Virol
. 2021 Mar;
95(11).
PMID: 33731460
In many enveloped virus families, including HIV and HSV, a crucial, yet unexploited, step in the viral life cycle is releasing particles from the infected cell membranes. This release process...
2.
Strickland M, Ehrlich L, Watanabe S, Khan M, Strub M, Luan C, et al.
Nat Commun
. 2017 Nov;
8(1):1391.
PMID: 29123089
HIV-1 replication requires Tsg101, a component of cellular endosomal sorting complex required for transport (ESCRT) machinery. Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can...
3.
Seo E, Leis J
Adv Virol
. 2012 Jun;
2012:532723.
PMID: 22666250
Pathogenic strains of viruses that infect humans are encapsulated in membranes derived from the host cell in which they infect. After replication, these viruses are released by a budding process...
4.
Kuang Z, Seo E, Leis J
J Virol
. 2011 May;
85(14):7153-61.
PMID: 21543490
Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex...
5.
Pincetic A, Kuang Z, Seo E, Leis J
J Virol
. 2010 Feb;
84(9):4725-36.
PMID: 20164219
The release of retroviruses from cells requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including the ESCRT-III proteins and the Vps4 ATPase. In response to...
6.
Pincetic A, Leis J
Adv Virol
. 2009 Oct;
2009:6239691-6239699.
PMID: 19865606
Retroviruses have evolved a mechanism for the release of particles from the cell membrane that appropriates cellular protein complexes, referred to as ESCRT-I, -II, -III, normally involved in the biogenesis...
7.
Dolan J, Chen A, Weber I, Harrison R, Leis J
J Mol Biol
. 2008 Nov;
385(2):568-79.
PMID: 19014951
A tetramer model for human immunodeficiency virus type 1 (HIV-1) integrase (IN) with DNA representing long terminal repeat (LTR) termini was previously assembled to predict the IN residues that interact...
8.
Pincetic A, Medina G, Carter C, Leis J
J Biol Chem
. 2008 Aug;
283(44):29822-30.
PMID: 18723511
Members of the Nedd4 family of E3 ubiquitin ligases bind the L domain in avian sarcoma virus (ASV) Gag and facilitate viral particle release. Translational fusion of ASV Gag with...
9.
Medina G, Pincetic A, Ehrlich L, Zhang Y, Tang Y, Leis J, et al.
Virology
. 2008 Jun;
377(1):30-8.
PMID: 18555885
The Late (L) domain of the avian sarcoma virus (ASV) Gag protein binds Nedd4 ubiquitin ligase E3 family members and is the determinant of efficient virus release in avian and...
10.
Chen A, Weber I, Harrison R, Leis J
J Biol Chem
. 2005 Nov;
281(7):4173-82.
PMID: 16298997
A tetramer model for HIV-1 integrase (IN) with DNA representing 20 bp of the U3 and U5 long terminal repeats (LTR) termini was assembled using structural and biochemical data and...