Einar M Sigurdsson
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Explore the profile of Einar M Sigurdsson including associated specialties, affiliations and a list of published articles.
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86
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6049
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Recent Articles
1.
Ji C, Yang X, Eleish M, Jiang Y, Tetlow A, Song S, et al.
Alzheimers Dement
. 2024 Oct;
20(11):7954-7970.
PMID: 39368113
Introduction: It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes in neuronal network activity, and if they can be alleviated with therapies. Methods:...
2.
Nair S, Jiang Y, Marchal I, Chernobelsky E, Huang H, Suh S, et al.
Cell Death Dis
. 2024 Jul;
15(7):543.
PMID: 39079958
Tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. We have developed over fifty anti-tau single-domain antibodies (sdAbs) derived from phage display libraries of a...
3.
Jiang Y, Lin Y, Tetlow A, Pan R, Ji C, Kong X, et al.
Mol Neurodegener
. 2024 May;
19(1):44.
PMID: 38816762
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for...
4.
Ji C, Yang X, Eleish M, Jiang Y, Tetlow A, Song S, et al.
bioRxiv
. 2024 May;
PMID: 38746288
Highlights: Layer 2/3 motor cortical neurons exhibited hypofunction in awake and behaving mice at the early stage of tauopathy.Altered neuronal network activity disrupted local circuitry engagement in tauopathy mice during...
5.
Jiang Y, Lin Y, Tetlow A, Pan R, Ji C, Kong X, et al.
bioRxiv
. 2024 Apr;
PMID: 38558982
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for...
6.
Sigurdsson E
J Alzheimers Dis
. 2024 Mar;
101(s1):S129-S140.
PMID: 38427486
The tau protein undergoes pathological changes in Alzheimer's disease and other tauopathies that eventually lead to functional impairments. Over the years, several therapeutic approaches have been examined to slow or...
7.
Congdon E, Ji C, Tetlow A, Jiang Y, Sigurdsson E
Nat Rev Neurol
. 2023 Oct;
19(12):715-736.
PMID: 37875627
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the brain, with associated...
8.
Banka V, Kelleher A, Sehlin D, Hultqvist G, Sigurdsson E, Syvanen S, et al.
Front Nucl Med
. 2023 Sep;
3.
PMID: 37680310
Introduction: Alzheimer's disease (AD) is characterized by the misfolding and aggregation of two major proteins: amyloid-beta (Aβ) and tau. Antibody-based PET radioligands are desirable due to their high specificity and...
9.
Jiang Y, Lin Y, Krishnaswamy S, Pan R, Wu Q, Sandusky-Beltran L, et al.
Sci Adv
. 2023 May;
9(19):eadf3775.
PMID: 37163602
Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers...
10.
Trouche S, Boutajangout A, Asuni A, Fontes P, Sigurdsson E, Verdier J, et al.
Brain Behav Immun
. 2023 Jan;
109:63-77.
PMID: 36592872
Non-human primates have an important translational value given their close phylogenetic relationship to humans. Studies in these animals remain essential for evaluating efficacy and safety of new therapeutic approaches, particularly...