Edward N Pugh Jr
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Explore the profile of Edward N Pugh Jr including associated specialties, affiliations and a list of published articles.
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4439
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Recent Articles
11.
Ronning K, Peinado Allina G, Miller E, Zawadzki R, Pugh Jr E, Herrmann R, et al.
Exp Eye Res
. 2018 Mar;
171:111-118.
PMID: 29518352
Rods and cones mediate visual perception over 9 log units of light intensities, with both photoreceptor types contributing to a middle 3-log unit range that comprises most night-time conditions. Rod...
12.
Pugh Jr E
J Gen Physiol
. 2018 Feb;
150(3):383-388.
PMID: 29467164
Vertebrate rod photoreceptors evolved the astonishing ability to respond reliably to single photons. In parallel, the proximate neurons of the visual system evolved the ability to reliably encode information from...
13.
Lu C, Lee B, Schottenhamml J, Maier A, Pugh Jr E, Fujimoto J
Invest Ophthalmol Vis Sci
. 2017 Sep;
58(11):4632-4643.
PMID: 28898357
Purpose: To examine outer retinal band changes after flash stimulus and subsequent dark adaptation with ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods: Five dark-adapted left eyes of five normal subjects were...
14.
Wang X, Miller E, Goswami M, Zhang P, Ronning K, Karlen S, et al.
J Neuroinflammation
. 2017 Jun;
14(1):121.
PMID: 28645275
Background: Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL6,...
15.
Zhang P, Zawadzki R, Goswami M, Nguyen P, Yarov-Yarovoy V, Burns M, et al.
Proc Natl Acad Sci U S A
. 2017 Mar;
114(14):E2937-E2946.
PMID: 28320964
The light responses of rod and cone photoreceptors have been studied electrophysiologically for decades, largely with ex vivo approaches that disrupt the photoreceptors' subretinal microenvironment. Here we report the use...
16.
Peinado Allina G, Fortenbach C, Naarendorp F, Gross O, Pugh Jr E, Burns M
J Gen Physiol
. 2017 Mar;
149(4):443-454.
PMID: 28302678
The temporal resolution of scotopic vision is thought to be constrained by the signaling kinetics of retinal rods, which use a highly amplified G-protein cascade to transduce absorbed photons into...
17.
Zhang P, Goswami M, Zawadzki R, Pugh Jr E
Invest Ophthalmol Vis Sci
. 2016 Jul;
57(8):3650-64.
PMID: 27403994
Purpose: To quantify bleaching-induced changes in fundus reflectance in the mouse retina. Methods: Light reflected from the fundus of albino (Balb/c) and pigmented (C57Bl/6J) mice was measured with a multichannel...
18.
Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam K, et al.
J Biomed Opt
. 2015 Dec;
20(12):126005.
PMID: 26677070
Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the...
19.
Pugh Jr E
J Cell Biol
. 2015 Nov;
211(3):491-3.
PMID: 26527745
Vision begins in photoreceptor outer segments with light captured by opsins in continually synthesized disc membranes. The process by which rod photoreceptor discs are formed has been controversial. In this...
20.
Burns M, Levine E, Miller E, Zam A, Zhang P, Zawadzki R, et al.
Adv Exp Med Biol
. 2015 Oct;
854:269-75.
PMID: 26427421
Optical Coherence Tomography (OCT) is a powerful clinical tool that measures near infrared light backscattered from the eye and other tissues. OCT is used for assessing changes in retinal structure,...