Edward N Pugh Jr
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Explore the profile of Edward N Pugh Jr including associated specialties, affiliations and a list of published articles.
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78
Citations
4439
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Recent Articles
21.
Bonora S, Jian Y, Zhang P, Zam A, Pugh Jr E, Zawadzki R, et al.
Opt Express
. 2015 Sep;
23(17):21931-41.
PMID: 26368169
Adaptive optics is rapidly transforming microscopy and high-resolution ophthalmic imaging. The adaptive elements commonly used to control optical wavefronts are liquid crystal spatial light modulators and deformable mirrors. We introduce...
22.
Zawadzki R, Zhang P, Zam A, Miller E, Goswami M, Wang X, et al.
Biomed Opt Express
. 2015 Jun;
6(6):2191-210.
PMID: 26114038
Adaptive optics scanning laser ophthalmoscopy (AO-SLO) has recently been used to achieve exquisite subcellular resolution imaging of the mouse retina. Wavefront sensing-based AO typically restricts the field of view to...
23.
Gross O, Pugh Jr E, Burns M
Front Mol Neurosci
. 2015 Mar;
8:6.
PMID: 25788876
Vertebrate vision begins when retinal photoreceptors transduce photons into electrical signals that are then relayed to other neurons in the eye, and ultimately to the brain. In rod photoreceptors, transduction...
24.
Zhang T, Enemchukwu N, Jones A, Wang S, Dennis E, Watt C, et al.
Hum Mol Genet
. 2014 Nov;
24(6):1755-63.
PMID: 25416279
Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (LCA), a severe hereditary blindness occurring in early childhood. The pathology is attributed to a...
25.
Levine E, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, et al.
Vision Res
. 2014 Aug;
102:71-9.
PMID: 25091460
Microglia dynamically prune synaptic contacts during development, and digest waste that accumulates in degeneration and aging. In many neurodegenerative diseases, microglial activation and phagocytosis gradually increase over months or years,...
26.
Kessler C, Tillman M, Burns M, Pugh Jr E
J Physiol
. 2014 May;
592(13):2785-97.
PMID: 24801306
Sustained vertebrate vision requires that opsin chromophores isomerized by light to the all-trans form be replaced with 11-cis retinal to regenerate the visual pigment. We have characterized the early receptor...
27.
Haeri M, Calvert P, Solessio E, Pugh Jr E, Knox B
PLoS One
. 2013 Nov;
8(11):e80059.
PMID: 24260336
The rod outer segment (OS), comprised of tightly stacked disk membranes packed with rhodopsin, is in a dynamic equilibrium governed by a diurnal rhythm with newly synthesized membrane inserted at...
28.
29.
Zawadzki R, Pugh Jr E
Invest Ophthalmol Vis Sci
. 2013 Apr;
54(4):2991.
PMID: 23612484
No abstract available.
30.
Nikonov S, Lyubarsky A, Fina M, Nikonova E, Sengupta A, Chinniah C, et al.
J Neurosci
. 2013 Mar;
33(12):5182-94.
PMID: 23516284
Mammalian cones respond to light by closing a cGMP-gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Gαt2, Gβ3 and Gγt2 subunits. The function of Gβγ...