Edward K Lobenhofer
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Explore the profile of Edward K Lobenhofer including associated specialties, affiliations and a list of published articles.
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2765
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Recent Articles
1.
Giffin M, Cooke K, Lobenhofer E, Estrada J, Zhan J, Deegen P, et al.
Clin Cancer Res
. 2020 Nov;
27(5):1526-1537.
PMID: 33203642
Purpose: Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a high relapse rate, limited therapeutic options, and poor prognosis. We investigated the antitumor activity of AMG 757, a...
2.
Lafleur M, Werner J, Fort M, Lobenhofer E, Balazs M, Goyos A
J Immunotoxicol
. 2020 Jun;
17(1):110-121.
PMID: 32525431
Mast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a wide spectrum of pleotropic mediators that are released upon activation....
3.
Wurz R, Pettus L, Ashton K, Brown J, Chen J, Herberich B, et al.
ACS Med Chem Lett
. 2015 Sep;
6(9):987-92.
PMID: 26396685
In nonsmall cell lung cancer (NSCLC), the threonine(790)-methionine(790) (T790M) point mutation of EGFR kinase is one of the leading causes of acquired resistance to the first generation tyrosine kinase inhibitors...
4.
Shi L, Campbell G, Jones W, Campagne F, Wen Z, Walker S, et al.
Nat Biotechnol
. 2010 Aug;
28(8):827-38.
PMID: 20676074
Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent...
5.
Alexeyenko A, Wassenberg D, Lobenhofer E, Yen J, Linney E, Sonnhammer E, et al.
PLoS One
. 2010 May;
5(5):e10465.
PMID: 20463971
Background: In order to generate hypotheses regarding the mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) causes toxicity, we analyzed global gene expression changes in developing zebrafish embryos exposed to this potent toxicant...
6.
Wade H, Kobayashi S, Eaton M, Jansen M, Lobenhofer E, Lupien M, et al.
Mol Cell Biol
. 2010 Feb;
30(8):1866-77.
PMID: 20123965
An analysis of mRNA expression in T47D breast cancer cells treated with the synthetic progestin R5020 revealed a subset of progesterone receptor (PR) target genes that are enriched for E2F...
7.
Mei N, Fuscoe J, Lobenhofer E, Guo L
Methods Mol Biol
. 2009 Dec;
597:227-41.
PMID: 20013237
The field of toxicogenomics, which is becoming an important sub-discipline of toxicology, resulted from the natural convergence of the field of conventional toxicological research and the emergent field of functional...
8.
Nehme A, Lobenhofer E, Stamer W, Edelman J
BMC Med Genomics
. 2009 Sep;
2:58.
PMID: 19744340
Background: In addition to their well-documented ocular therapeutic effects, glucocorticoids (GCs) can cause sight-threatening side-effects including ocular hypertension presumably via morphological and biochemical changes in trabecular meshwork (TM) cells. In...
9.
Trick M, Cheung F, Drou N, Fraser F, Lobenhofer E, Hurban P, et al.
BMC Plant Biol
. 2009 May;
9:50.
PMID: 19426481
Background: The Brassica species include an important group of crops and provide opportunities for studying the evolutionary consequences of polyploidy. They are related to Arabidopsis thaliana, for which the first...
10.
Demircan B, Dyer L, Gerace M, Lobenhofer E, Robertson K, Brown K
Genes Chromosomes Cancer
. 2008 Oct;
48(1):83-97.
PMID: 18836996
Gene silencing by aberrant epigenetic chromatin alteration is a well-recognized event contributing to tumorigenesis. Although genetically engineered tumor-prone mouse models have proven a powerful tool in understanding many aspects of...