Edward D Lowe
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Explore the profile of Edward D Lowe including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
1993
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Recent Articles
1.
Bo Z, Rowntree T, Johnson S, Nurmahdi H, Suckling R, Hill J, et al.
Structure
. 2024 Nov;
32(12):2325-2336.e5.
PMID: 39488203
The Notch receptor is activated by the Delta/Serrate/Lag-2 (DSL) family of ligands. The organization of the extracellular signaling complex is unknown, although structures of Notch/ligand complexes comprising the ligand-binding region...
2.
Abuhammad A, Laurieri N, Rice A, Lowe E, Singh N, Naser S, et al.
J Biomol Struct Dyn
. 2023 Feb;
41(23):14036-14048.
PMID: 36762717
Bipolar disorder is a major psychiatric disorder associated with cognitive impairment and a high suicide rate. Frontline therapy for this condition includes lithium (Li)-containing treatments that can exert severe side...
3.
Karagianni E, Kontomina E, Lowe E, Athanasopoulos K, Papanikolaou G, Garefalaki V, et al.
FEBS J
. 2022 Sep;
290(9):2412-2436.
PMID: 36178468
Fusarium endophytes damage cereal crops and contaminate produce with mycotoxins. Those fungi overcome the main chemical defence of host via detoxification by a malonyl-CoA-dependent enzyme homologous to xenobiotic metabolizing arylamine...
4.
Ragotte R, Pulido D, Lias A, Quinkert D, Alanine D, Jamwal A, et al.
Nat Commun
. 2022 Feb;
13(1):933.
PMID: 35177602
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly...
5.
Nair R, Seenivasan A, Liu B, Chen D, Lowe E, Lorenz S
ACS Chem Biol
. 2021 Aug;
16(9):1615-1621.
PMID: 34403242
Ubiquitin activity-based probes have proven invaluable in elucidating structural mechanisms in the ubiquitin system by stabilizing transient macromolecular complexes of deubiquitinases, ubiquitin-activating enzymes, and the assemblies of ubiquitin-conjugating enzymes with...
6.
Housden N, Webby M, Lowe E, El-Baba T, Kaminska R, Redfield C, et al.
Nat Commun
. 2021 Jul;
12(1):4625.
PMID: 34330923
Bacteria often secrete diffusible protein toxins (bacteriocins) to kill bystander cells during interbacterial competition. Here, we use biochemical, biophysical and structural analyses to show how a bacteriocin exploits TolC, a...
7.
Ludzia P, Lowe E, Marciano G, Mohammed S, Redfield C, Akiyoshi B
Structure
. 2021 Apr;
29(9):1014-1028.e8.
PMID: 33915106
The kinetochore is the macromolecular machinery that drives chromosome segregation by interacting with spindle microtubules. Kinetoplastids (such as Trypanosoma brucei), a group of evolutionarily divergent eukaryotes, have a unique set...
8.
Behrens H, Lowe E, Gault J, Housden N, Kaminska R, Weber T, et al.
mBio
. 2020 Mar;
11(2).
PMID: 32156826
Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human pathogen in animal infection models, but its import mechanism is poorly understood. Here, using crystallography, biophysical and biochemical...
9.
Ries L, Liess A, Feiler C, Spratt D, Lowe E, Lorenz S
Protein Sci
. 2020 Jan;
29(6):1550-1554.
PMID: 31994269
The HECT-type ubiquitin ligase E6AP (UBE3A) is critically involved in several neurodevelopmental disorders and human papilloma virus-induced cervical tumorigenesis; the structural mechanisms underlying the activity of this crucial ligase, however,...
10.
Grime G, Zeldin O, Snell M, Lowe E, Hunt J, Montelione G, et al.
J Am Chem Soc
. 2019 Dec;
142(1):185-197.
PMID: 31794207
Metalloproteins comprise over one-third of proteins, with approximately half of all enzymes requiring metal to function. Accurate identification of these metal atoms and their environment is a prerequisite to understanding...