Christina Redfield
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Explore the profile of Christina Redfield including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
1043
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Recent Articles
1.
Buchanan C, Karunanithy G, Tkachenko O, Barber M, Marty M, Nott T, et al.
Nat Commun
. 2025 Jan;
16(1):449.
PMID: 39773982
To extract information from NMR experiments, users need to identify the number of resonances in the spectrum, together with characteristic features such as chemical shifts and intensities. In many applications,...
2.
Song W, Zhao Y, Ruggiano A, Redfield C, Newman J, Zhu X, et al.
bioRxiv
. 2024 Dec;
PMID: 39651247
DNA-protein crosslinks (DPCs) are endogenous and chemotherapy-induced genotoxic DNA lesions and, if not repaired, lead to embryonic lethality, neurodegeneration, premature ageing, and cancer. DPCs are heavily polyubiquitinated, and the SPRTN...
3.
Ludzia P, Ishii M, Deak G, Spanos C, Wilson M, Redfield C, et al.
Structure
. 2024 Nov;
33(1):123-135.e10.
PMID: 39579771
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. In an evolutionarily divergent group of organisms called kinetoplastids, kinetochores are built using a unique set of...
4.
Bo Z, Rowntree T, Johnson S, Nurmahdi H, Suckling R, Hill J, et al.
Structure
. 2024 Nov;
32(12):2325-2336.e5.
PMID: 39488203
The Notch receptor is activated by the Delta/Serrate/Lag-2 (DSL) family of ligands. The organization of the extracellular signaling complex is unknown, although structures of Notch/ligand complexes comprising the ligand-binding region...
5.
Kuravsky M, Kelly C, Redfield C, Shammas S
Nucleic Acids Res
. 2024 Sep;
52(19):11822-11837.
PMID: 39315703
The basic zippers (bZIPs) are one of two large eukaryotic families of transcription factors whose DNA binding domains are disordered in isolation but fold into stable α-helices upon target DNA...
6.
Ludzia P, Hayashi H, Robinson T, Akiyoshi B, Redfield C
Biomol NMR Assign
. 2024 Mar;
18(1):15-25.
PMID: 38453826
KKT4 is a multi-domain kinetochore protein specific to kinetoplastids, such as Trypanosoma brucei. It lacks significant sequence similarity to known kinetochore proteins in other eukaryotes. Our recent X-ray structure of...
7.
Crabtree M, Holland J, Pillai A, Kompella P, Babl L, Turner N, et al.
Cell Rep
. 2023 Nov;
42(11):113375.
PMID: 37980572
Membraneless organelles, or biomolecular condensates, enable cells to compartmentalize material and processes into unique biochemical environments. While specific, attractive molecular interactions are known to stabilize biomolecular condensates, repulsive interactions, and...
8.
Vaz D, Rodrigues J, Loureiro-Ferreira N, Muller T, Sebald W, Redfield C, et al.
Proteins
. 2023 Oct;
92(2):219-235.
PMID: 37814578
Interleukin-4 (IL-4) is a hematopoietic cytokine composed by a four-helix bundle stabilized by an antiparallel beta-sheet and three disulfide bonds: Cys3-Cys127, Cys24-Cys65, and Cys46-Cys99. IL-4 is involved in several immune...
9.
Wang D, Vidovic D, McKay A, Darwish T, Park H, Garza S, et al.
Anal Chem
. 2022 Sep;
94(38):12971-12980.
PMID: 36098546
Ru-based catalysis results in highly unsaturated fatty acid (HUFA) ethyl esters (EE) deuterated to various extents. The products carry H (D) mainly at their -allylic positions, where they are resistant...
10.
Landin E, Williams C, Ryan S, Bochel A, Akter N, Redfield C, et al.
J Biol Chem
. 2021 Nov;
297(6):101392.
PMID: 34758357
The α1-acid glycoprotein (AGP) is an abundant blood plasma protein with important immunomodulatory functions coupled to endogenous and exogenous ligand-binding properties. Its affinity for many drug-like structures, however, means AGP...