Colin Kleanthous
Overview
Explore the profile of Colin Kleanthous including associated specialties, affiliations and a list of published articles.
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116
Citations
3229
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Recent Articles
1.
Kumar S, Inns P, Ward S, Lagage V, Wang J, Kaminska R, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2414725122.
PMID: 40030021
The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the classical model of an asymmetric lipid bilayer, recent evidence...
2.
Goult J, Van D, Taylor Y, Inns P, Kaminska R, Vesely M, et al.
PNAS Nexus
. 2024 Apr;
3(4):pgae124.
PMID: 38577260
TonB-dependent transporters (TBDTs) mediate energized transport of essential nutrients into gram-negative bacteria. TBDTs are increasingly being exploited for the delivery of antibiotics to drug-resistant bacteria. While much is known about...
3.
Williams-Jones D, Webby M, Press C, Gradon J, Armstrong S, Szczepaniak J, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2306707120.
PMID: 37972066
The outer membrane (OM) of Gram-negative bacteria is not energised and so processes requiring a driving force must connect to energy-transduction systems in the inner membrane (IM). Tol (Tol-Pal) and...
4.
Benn G, Silhavy T, Kleanthous C, Hoogenboom B
Nat Commun
. 2023 Aug;
14(1):4772.
PMID: 37558670
No abstract available.
5.
Premsuriya J, Mosbahi K, Atanaskovic I, Kleanthous C, Walker D
Biochem J
. 2023 Jul;
480(14):1035-1049.
PMID: 37399084
Pseudomonas aeruginosa is a common cause of serious hospital-acquired infections, the leading proven cause of mortality in people with cystic fibrosis and is associated with high levels of antimicrobial resistance....
6.
Webby M, Oluwole A, Pedebos C, Inns P, Olerinyova A, Prakaash D, et al.
Sci Adv
. 2022 Nov;
8(44):eadc9566.
PMID: 36322653
β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form is unknown. Here, through photoactivatable...
7.
Mamou G, Corona F, Cohen-Khait R, Housden N, Yeung V, Sun D, et al.
Nature
. 2022 Jun;
606(7916):953-959.
PMID: 35705811
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and enable survival in challenging environments. The function of the...
8.
Atanaskovic I, Sharp C, Press C, Kaminska R, Kleanthous C
mBio
. 2022 Mar;
13(2):e0339621.
PMID: 35343790
Bacteria exploit a variety of attack strategies to gain dominance within ecological niches. Prominent among these are contact-dependent inhibition (CDI), type VI secretion (T6SS), and bacteriocins. The cytotoxic endpoint of...
9.
Webby M, Williams-Jones D, Press C, Kleanthous C
Front Microbiol
. 2022 Mar;
13:852176.
PMID: 35308353
The Tol-Pal system spans the cell envelope of Gram-negative bacteria, transducing the potential energy of the proton motive force (PMF) into dissociation of the TolB-Pal complex at the outer membrane...
10.
Connolley L, Szczepaniak J, Kleanthous C, Murray S
PLoS Comput Biol
. 2021 Dec;
17(12):e1009756.
PMID: 34965245
The spatial localisation of proteins is critical for most cellular function. In bacteria, this is typically achieved through capture by established landmark proteins. However, this requires that the protein is...