Edward C Twomey
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Explore the profile of Edward C Twomey including associated specialties, affiliations and a list of published articles.
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19
Citations
729
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Recent Articles
11.
Twomey E, Yelshanskaya M, Vassilevski A, Sobolevsky A
Neuron
. 2018 Aug;
99(5):956-968.e4.
PMID: 30122377
AMPA receptors mediate fast excitatory neurotransmission and are critical for CNS development and function. Calcium-permeable subsets of AMPA receptors are strongly implicated in acute and chronic neurological disorders. However, despite...
12.
Singh A, McGoldrick L, Twomey E, Sobolevsky A
Sci Adv
. 2018 Aug;
4(8):eaau6088.
PMID: 30116787
Calcium (Ca) plays a major role in numerous physiological processes. Ca homeostasis is tightly controlled by ion channels, the aberrant regulation of which results in various diseases including cancers. Calmodulin...
13.
McGoldrick L, Singh A, Saotome K, Yelshanskaya M, Twomey E, Grassucci R, et al.
Nature
. 2017 Dec;
553(7687):233-237.
PMID: 29258289
Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human...
14.
Twomey E, Sobolevsky A
Biochemistry
. 2017 Oct;
57(3):267-276.
PMID: 29037031
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion channels in response to binding of...
15.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Nature
. 2017 Jul;
549(7670):60-65.
PMID: 28737760
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation...
16.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Neuron
. 2017 May;
94(3):569-580.e5.
PMID: 28472657
Fast excitatory neurotransmission is mediated by AMPA-subtype ionotropic glutamate receptors (AMPARs). AMPARs, localized at post-synaptic densities, are regulated by transmembrane auxiliary subunits that modulate AMPAR assembly, trafficking, gating, and pharmacology....
17.
Twomey E, Yelshanskaya M, Grassucci R, Frank J, Sobolevsky A
Science
. 2016 Jul;
353(6294):83-6.
PMID: 27365450
AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to high cognitive processes such as learning and memory. In the brain, AMPAR trafficking, gating, and pharmacology is tightly...
18.
Twomey E, Cordasco D, Kozuch S, Wei Y
PLoS One
. 2014 Jan;
8(12):e83421.
PMID: 24391764
Protein conformational changes are commonly associated with the formation of protein complexes. The non-catalytic death effector domains (DEDs) mediate protein-protein interactions in a variety of cellular processes, including apoptosis, proliferation...
19.
Twomey E, Cordasco D, Wei Y
Biochim Biophys Acta
. 2012 Jul;
1824(12):1382-93.
PMID: 22820249
PED/PEA-15 is a small, non-catalytic, DED containing protein that is widely expressed in different tissues and highly conserved among mammals. PED/PEA-15 has been found to interact with several protein targets...
20.
Twomey E, Wei Y
Biochem Biophys Res Commun
. 2012 Jun;
424(1):141-6.
PMID: 22732408
Death effector domain (DED) proteins constitute a subfamily of the large death domain superfamily that is primarily involved in apoptosis pathways. DED structures have characteristic side chain-side chain interactions among...