Edith McGeer
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Explore the profile of Edith McGeer including associated specialties, affiliations and a list of published articles.
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14
Citations
412
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Recent Articles
1.
McGeer P, McGeer E
J Alzheimers Dis
. 2018 Mar;
64(s1):S361-S363.
PMID: 29562519
The means are now at hand to conquer Alzheimer's disease (AD). The method is to identify those at risk for the disease before clinical signs develop. That is followed by...
2.
Lee M, Wathier M, Love J, McGeer E, McGeer P
Neurobiol Aging
. 2015 Aug;
36(10):2748-56.
PMID: 26248865
We here report synthesis for the first time of the acetyl salicylic acid dimer 5,5'-methylenebis(2-acetoxybenzoic acid) (DAS). DAS inhibits aberrant complement activation by selectively blocking factor D of the alternative...
3.
Lee M, Shi X, Barron A, McGeer E, McGeer P
Biochem Pharmacol
. 2015 Feb;
94(2):130-41.
PMID: 25686659
LL-37 is the sole cathelicidin-derived antimicrobial peptide found in humans. It becomes active upon C-terminal cleavage of its inactive precursor hCAP18. In addition to antimicrobial action, it also functions as...
4.
Lee M, McGeer E, McGeer P
Neurobiol Aging
. 2014 Aug;
36(1):42-52.
PMID: 25169677
Neuroinflammation is hypothesized to be a major driving force behind Alzheimer's disease (AD) pathogenesis. This hypothesis predicts that activated microglial cells can stimulate neurons to produce excessive amounts of β-amyloid...
5.
Lee M, McGeer E, Kodela R, Kashfi K, McGeer P
Glia
. 2013 Aug;
61(10):1724-34.
PMID: 23918470
Hydrogen sulfide (H2 S) and nitric oxide (NO) have been described as gasotransmitters. Anti-inflammatory activity in the central and peripheral nervous systems may be one of their functions. Previously we...
6.
Lee M, Kwon B, Kwon B, Suk K, McGeer E, McGeer P
J Neuroimmune Pharmacol
. 2011 Jul;
7(1):173-86.
PMID: 21796424
Earlier studies indicate that obovatol (OBO), isolated from a medicinal herb Magnolia obovata, has anti-inflammatory and anti-oxidative properties. Depletion of glutathione (GSH) in glial cells with the γ-glutamylcysteine synthase inhibitor...
7.
Lee M, Suk K, Kang Y, McGeer E, McGeer P
Brain Res
. 2011 Jun;
1400:99-111.
PMID: 21640980
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes...
8.
Lee M, Jantaratnotai N, McGeer E, McLarnon J, McGeer P
Brain Res
. 2010 Nov;
1369:21-35.
PMID: 21040713
Mg(2+) is a known antagonist of some Ca(2+) ion channels. It may therefore be able to counteract the toxic consequences of excessive Ca(2+) entry into immune-type cells. Here we examined...
9.
Lee M, Tazzari V, Giustarini D, Rossi R, Sparatore A, Del Soldato P, et al.
J Biol Chem
. 2010 Apr;
285(23):17318-28.
PMID: 20368333
The main lesion in Parkinson disease (PD) is loss of substantia nigra dopaminergic neurons. Levodopa (L-DOPA) is the most widely used therapy, but it does not arrest disease progression. Some...
10.
Lee M, Cho T, Jantaratnotai N, Wang Y, McGeer E, McGeer P
FASEB J
. 2010 Mar;
24(7):2533-45.
PMID: 20228251
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y...