Piero Del Soldato
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Explore the profile of Piero Del Soldato including associated specialties, affiliations and a list of published articles.
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77
Citations
1468
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Recent Articles
1.
Huang Q, Sparatore A, Del Soldato P, Wu L, Desai K
PLoS One
. 2014 Jun;
9(6):e97315.
PMID: 24896242
Hydrogen sulfide is a gasotransmitter with vasodilatory and anti-inflammatory properties. Aspirin is an irreversible cyclooxygenase inhibitor anti-inflammatory drug. ACS14 is a novel synthetic hydrogen sulfide releasing aspirin which inhibits cyclooxygenase...
2.
Xie L, Hu L, Teo X, Tiong C, Tazzari V, Sparatore A, et al.
PLoS One
. 2013 Apr;
8(4):e60200.
PMID: 23573240
Parkinson's disease (PD), characterized by loss of dopaminergic neurons in the substantia nigra, is a neurodegenerative disorder of central nervous system. The present study was designed to investigate the therapeutic...
3.
Liu L, Cui J, Song C, Bian J, Sparatore A, Del Soldato P, et al.
PLoS One
. 2012 Oct;
7(9):e46301.
PMID: 23029468
The aim of this study was to examine the effect of ACS14, a hydrogen sulfide (H(2)S)-releasing derivative of aspirin (Asp), on Asp-induced gastric injury. Gastric hemorrhagic lesions were induced by...
4.
Pircher J, Fochler F, Czermak T, Mannell H, Kraemer B, Wornle M, et al.
Arterioscler Thromb Vasc Biol
. 2012 Oct;
32(12):2884-91.
PMID: 23023375
Objective: Hydrogen sulfide (H(2)S)-releasing NSAIDs exert potent anti-inflammatory effects beyond classical cyclooxygenase inhibition. Here, we compared the platelet inhibitory effects of the H(2)S-releasing aspirin derivative ACS14 with its mother compound...
5.
Tang X, Chen R, Dong L, Ren Y, Del Soldato P, Sparatore A, et al.
J Mol Neurosci
. 2012 Jul;
50(1):70-7.
PMID: 22843253
ACS6, a novel hydrogen sulfide (H2S)-releasing sildenafil, has been demonstrated to inhibit superoxide formation through donating H2S. We have previously found that ACS6 antagonizes homocysteine-induced apoptosis and cytotoxicity. The aim...
6.
Switzer C, Cheng R, Ridnour L, Murray M, Tazzari V, Sparatore A, et al.
Cancer Res
. 2012 Mar;
72(9):2394-404.
PMID: 22436383
The NF-κB transcription factor family influences breast cancer outcomes by regulating genes involved in tumor progression, angiogenesis, and metastasis. Dithiolethiones, a class of naturally occurring compounds with cancer chemoprevention effects...
7.
Tesei A, Brigliadori G, Carloni S, Fabbri F, Ulivi P, Arienti C, et al.
J Cell Physiol
. 2012 Jan;
227(10):3389-96.
PMID: 22212895
Lung cancer is the leading cause of cancer mortality worldwide and despite efforts made to improve clinical results, continuing poor survival rates indicate that novel therapeutic approaches are needed. Valproic...
8.
Tang X, Chen R, Ren Y, Del Soldato P, Sparatore A, Zhuang Y, et al.
Med Gas Res
. 2011 Dec;
1(1):20.
PMID: 22146536
Background: The hydrogen sulfide-releasing sildenafil, ACS6, has been demonstrated to inhibit superoxide formation through donating hydrogen sulfide (H2S). We have found that H2S antagonizes homocysteine-induced oxidative stress and neurotoxicity. The...
9.
Sparatore A, Santus G, Giustarini D, Rossi R, Del Soldato P
Expert Rev Clin Pharmacol
. 2011 Nov;
4(1):109-21.
PMID: 22115352
A new class of hydrogen sulfide (H(2)S)-donating hybrids combined with pharmacologically active compounds is presented in this article. The pharmacological profiles of some hybrid lead compounds in the areas of...
10.
Liu Y, Sparatore A, Del Soldato P, Bian J
Neurochem Int
. 2011 Feb;
58(5):591-8.
PMID: 21300120
Hydrogen sulfide (H(2)S) is a novel neurotransmitter. We studied here the effect of ACS 84, a new H(2)S releasing compound, on the cytotoxicity induced by amyloid beta (Aβ) in microglia....