Edgar G Engleman
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Explore the profile of Edgar G Engleman including associated specialties, affiliations and a list of published articles.
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95
Citations
5891
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Recent Articles
11.
Hongo D, Zheng P, Dutt S, Pawar R, Meyer E, Engleman E, et al.
Front Immunol
. 2021 Nov;
12:746469.
PMID: 34777358
Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8Irf8Batf3 dependent (DC1) subset, and a CD8Irf4 (DC2)...
12.
Barnes S, Zera K, Ivison G, Buckwalter M, Engleman E
J Neuroinflammation
. 2021 Sep;
18(1):199.
PMID: 34511110
Background: Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the mechanistic basis for these...
13.
Jensen K, Hongo D, Ji X, Zheng P, Pawar R, Wu T, et al.
Blood Adv
. 2021 Aug;
5(17):3290-3302.
PMID: 34432869
Replacement of failed organs followed by safe withdrawal of immunosuppressive drugs has long been the goal of organ transplantation. We studied changes in the balance of T cells and myeloid...
14.
Penny H, Sieow J, Gun S, Lau M, Lee B, Tan J, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34198548
Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an...
15.
Ouyang X, Liu Y, Zhou Y, Guo J, Wei T, Liu C, et al.
Stem Cell Reports
. 2021 May;
16(6):1468-1477.
PMID: 33961792
Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic...
16.
Chakraborty M, Chu K, Shrestha A, Revelo X, Zhang X, Gold M, et al.
Cell Rep
. 2021 Jan;
34(2):108609.
PMID: 33440149
Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood. Here, we show that static tension impacts...
17.
Marshall P, Nagy N, Kaber G, Barlow G, Ramesh A, Xie B, et al.
Matrix Biol
. 2020 Dec;
96:69-86.
PMID: 33290836
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation....
18.
Yuan R, Bhattacharya N, Kenkel J, Shen J, DiMaio M, Bagchi S, et al.
Front Oncol
. 2020 Dec;
10:595892.
PMID: 33282743
Enteric glia are a distinct population of peripheral glial cells in the enteric nervous system that regulate intestinal homeostasis, epithelial barrier integrity, and gut defense. Given these unique attributes, we...
19.
Bagchi S, Yuan R, Engleman E
Annu Rev Pathol
. 2020 Nov;
16:223-249.
PMID: 33197221
Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer immunotherapy. Starting with the approval of anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA-4) for advanced-stage melanoma in...
20.
Zhang X, Zheng P, Prestwood T, Zhang H, Carmi Y, Tolentino L, et al.
Front Immunol
. 2020 Sep;
11:1982.
PMID: 32973804
Dendritic cells (DCs) are powerful antigen presenting cells, derived from bone marrow progenitors (cDCs) and monocytes (moDCs), that can shape the immune response by priming either proinflammatory or tolerogenic immune...