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E Stuart Maxwell

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Articles 20
Citations 479
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Recent Articles
1.
Gagnon K, Maxwell E
Methods Mol Biol . 2014 Oct; 1240:125-34. PMID: 25352141
Heavy metal cleavage mapping analysis of both assembling and fully mature ribonucleoprotein (RNP) complexes are informative techniques for assessing the intermolecular base pairing between small non-coding RNAs and their interacting...
2.
Gagnon K, Biswas S, Zhang X, Brown 2nd B, Wollenzien P, Mattos C, et al.
J Biol Chem . 2012 Apr; 287(23):19418-28. PMID: 22496443
Box C/D RNA-protein complexes (RNPs) guide the 2'-O-methylation of nucleotides in both archaeal and eukaryotic ribosomal RNAs. The archaeal box C/D and C'/D' RNP subcomplexes are each assembled with three...
3.
Biswas S, Buhrman G, Gagnon K, Mattos C, Brown 2nd B, Maxwell E
Biochemistry . 2011 Mar; 50(14):2907-18. PMID: 21366326
Box C/D ribonucleoproteins (RNP) guide the 2'-O-methylation of targeted nucleotides in archaeal and eukaryotic rRNAs. The archaeal L7Ae and eukaryotic 15.5kD box C/D RNP core protein homologues initiate RNP assembly...
4.
Gagnon K, Maxwell E
Methods Mol Biol . 2010 Dec; 703:275-91. PMID: 21125497
Electrophoretic mobility shift assay, or EMSA, is a well-established technique for separating macromolecules under native conditions based on a combination of shape, size, and charge. The use of EMSA can...
5.
Qu G, van Nues R, Watkins N, Maxwell E
Mol Cell Biol . 2010 Nov; 31(2):365-74. PMID: 21041475
Box C/D ribonucleoprotein particles guide the 2'-O-ribose methylation of target nucleotides in both archaeal and eukaryotic RNAs. These complexes contain two functional centers, assembled around the C/D and C'/D' motifs...
6.
Xue S, Wang R, Yang F, Terns R, Terns M, Zhang X, et al.
Mol Cell . 2010 Sep; 39(6):939-49. PMID: 20864039
Box C/D small nucleolar and Cajal body ribonucleoprotein particles (sno/scaRNPs) direct site-specific 2'-O-methylation of ribosomal and spliceosomal RNAs and are critical for gene expression. Here we report crystal structures of...
7.
Gagnon K, Zhang X, Qu G, Biswas S, Suryadi J, Brown 2nd B, et al.
RNA . 2009 Nov; 16(1):79-90. PMID: 19926724
The archaeal L7Ae and eukaryotic 15.5kD protein homologs are members of the L7Ae/15.5kD protein family that characteristically recognize K-turn motifs found in both archaeal and eukaryotic RNAs. In Archaea, the...
8.
Bleichert F, Gagnon K, Brown 2nd B, Maxwell E, Leschziner A, Unger V, et al.
Science . 2009 Sep; 325(5946):1384-7. PMID: 19745151
Methylation of ribosomal RNA (rRNA) is required for optimal protein synthesis. Multiple 2'-O-ribose methylations are carried out by box C/D guide ribonucleoproteins [small ribonucleoproteins (sRNPs) and small nucleolar ribonucleoproteins (snoRNPs)],...
9.
Gagnon K, Ju S, Goshe M, Maxwell E, Franzen S
Nucleic Acids Res . 2009 Mar; 37(9):3074-82. PMID: 19304744
New classes of RNA enzymes or ribozymes have been obtained by in vitro evolution and selection of RNA molecules. Incorporation of modified nucleotides into the RNA sequence has been proposed...
10.
Tang G, Maxwell E
Genome Res . 2007 Nov; 18(1):104-12. PMID: 18032731
The amphibian Xenopus provides a model organism for investigating microRNA expression during vertebrate embryogenesis and development. Searching available Xenopus genome databases using known human pre-miRNAs as query sequences, more than...