Dunrui Wang
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Explore the profile of Dunrui Wang including associated specialties, affiliations and a list of published articles.
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25
Citations
364
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Recent Articles
1.
Tripathi B, Hirsh N, Qian X, Durkin M, Wang D, Papageorge A, et al.
Nat Cancer
. 2024 Nov;
5(12):1902-1918.
PMID: 39528835
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interaction with its effectors at the plasma membrane. Here, we identified a fundamental, oncogenic, noncanonical RAS•GTP activity that...
2.
Zhang T, Li S, Tan Y, Chen X, Zhang C, Chen Z, et al.
Cancer Lett
. 2024 Sep;
604:217240.
PMID: 39265800
Nuclear Bcl-xL is found to promote cancer metastasis independently of its mitochondria-based anti-apoptotic activity. How Bcl-xL is translocated into the nucleus and how nuclear Bcl-xL regulates histone H3 trimethyl Lys4...
3.
Wang D, Qian X, Du Y, Sanchez-Solana B, Chen K, Kanigicherla M, et al.
J Biotechnol Biomed
. 2024 Jun;
6(4):573-578.
PMID: 38938288
We developed cProSite, a website that provides online genomics, proteomics, and phosphoproteomics analysis for the data of The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC). This tool focuses...
4.
Zhang T, Li S, Tan Y, Na J, Chen Z, Damle P, et al.
bioRxiv
. 2023 May;
PMID: 37163116
Besides its mitochondria-based anti-apoptotic role, Bcl-xL also travels to the nucleus to promote cancer metastasis by upregulating global histone H3 trimethyl Lys4 (H3K4me3) and TGFβ transcription. How Bcl-xL is translocated...
5.
Tripathi B, Anderman M, Bhargava D, Boccuzzi L, Qian X, Wang D, et al.
Nat Commun
. 2021 Dec;
12(1):6941.
PMID: 34862367
mRNA expression of the DLC1 tumor suppressor gene is downregulated in many lung cancers and their derived cell lines, with DLC1 protein levels being low or absent. Although the role...
6.
Sanchez-Solana B, Wang D, Qian X, Velayoudame P, Simanshu D, Acharya J, et al.
Mol Cancer
. 2021 Nov;
20(1):141.
PMID: 34727930
Background: DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor...
7.
Wang Y, Salvucci O, Ohnuki H, Tran A, Ha T, Feng J, et al.
EMBO Mol Med
. 2021 Jun;
13(7):e14089.
PMID: 34102002
The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor-tyrosine-kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival...
8.
Lin A, Feng J, Chen X, Wang D, Wong M, Zhang G, et al.
Cancer Lett
. 2021 May;
514:79-89.
PMID: 34044069
Pancreatic cancer has the lowest survival rate out of all types of cancer. Pancreatic cancer patients are often diagnosed at advanced stages, hence an urgent need for a better therapeutic...
9.
Wang D, Qian X, Sanchez-Solana B, Tripathi B, Durkin M, Lowy D
Cancer Res
. 2020 Jul;
80(17):3568-3579.
PMID: 32606003
In advanced cancer, the RHOA GTPase is often active together with reduced expression of genes encoding Rho-specific GTPase-accelerating proteins (Rho-GAP), which negatively regulate RHOA and related GTPases. Here we used...
10.
DiPrima M, Wang D, Troster A, Maric D, Terrades-Garcia N, Ha T, et al.
Mol Oncol
. 2019 Sep;
13(11):2441-2459.
PMID: 31545551
Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine-dependent Eph receptor signaling sustains colorectal carcinoma cell survival, thereby uncovering a survival pathway active...