Alex G Papageorge
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Explore the profile of Alex G Papageorge including associated specialties, affiliations and a list of published articles.
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10
Citations
390
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Recent Articles
1.
Tripathi B, Hirsh N, Qian X, Durkin M, Wang D, Papageorge A, et al.
Nat Cancer
. 2024 Nov;
5(12):1902-1918.
PMID: 39528835
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interaction with its effectors at the plasma membrane. Here, we identified a fundamental, oncogenic, noncanonical RAS•GTP activity that...
2.
Tripathi B, Anderman M, Bhargava D, Boccuzzi L, Qian X, Wang D, et al.
Nat Commun
. 2021 Dec;
12(1):6941.
PMID: 34862367
mRNA expression of the DLC1 tumor suppressor gene is downregulated in many lung cancers and their derived cell lines, with DLC1 protein levels being low or absent. Although the role...
3.
Zhang H, Schaefer A, Wang Y, Hodge R, Blake D, Diehl J, et al.
Cancer Discov
. 2019 Nov;
10(2):288-305.
PMID: 31771969
Diffuse gastric cancer (DGC) is a lethal malignancy lacking effective systemic therapy. Among the most provocative recent results in DGC has been that of highly recurrent missense mutations in the...
4.
Tripathi B, Anderman M, Qian X, Zhou M, Wang D, Papageorge A, et al.
J Cell Biol
. 2019 Jul;
218(9):3060-3076.
PMID: 31308216
SRC and ERK kinases control many cell biological processes that promote tumorigenesis by altering the activity of oncogenic and tumor suppressor proteins. We identify here a physiological interaction between DLC1,...
5.
Castel P, Cheng A, Cuevas-Navarro A, Everman D, Papageorge A, Simanshu D, et al.
Science
. 2019 Mar;
363(6432):1226-1230.
PMID: 30872527
RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. Despite the resemblance of RIT1 to other members of the Ras small guanosine triphosphatases (GTPases), mutations affecting...
6.
Tripathi B, Grant T, Qian X, Zhou M, Mertins P, Wang D, et al.
J Cell Biol
. 2017 Nov;
216(12):4255-4270.
PMID: 29114068
We report several receptor tyrosine kinase (RTK) ligands increase RhoA-guanosine triphosphate (GTP) in untransformed and transformed cell lines and determine this phenomenon depends on the RTKs activating the AKT serine/threonine...
7.
Tripathi B, Qian X, Mertins P, Wang D, Papageorge A, Carr S, et al.
J Cell Biol
. 2014 Dec;
207(5):627-42.
PMID: 25452387
DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including...
8.
Li G, Du X, Vass W, Papageorge A, Lowy D, Qian X
Proc Natl Acad Sci U S A
. 2011 Oct;
108(41):17129-34.
PMID: 21969587
The deleted in liver cancer 1 (DLC1) tumor suppressor gene, which is frequently inactivated in cancer, encodes a Rho-GAP (GTPase activating protein) focal adhesion protein whose negative regulation of Rho-GTPases...
9.
Crawford N, Qian X, Ziogas A, Papageorge A, Boersma B, Walker R, et al.
PLoS Genet
. 2007 Dec;
3(11):e214.
PMID: 18081427
A novel candidate metastasis modifier, ribosomal RNA processing 1 homolog B (Rrp1b), was identified through two independent approaches. First, yeast two-hybrid, immunoprecipitation, and functional assays demonstrated a physical and functional...
10.
Qian X, Li G, Asmussen H, Asnaghi L, Vass W, Braverman R, et al.
Proc Natl Acad Sci U S A
. 2007 May;
104(21):9012-7.
PMID: 17517630
The three deleted in liver cancer genes (DLC1-3) encode Rho-GTPase-activating proteins (RhoGAPs) whose expression is frequently down-regulated or silenced in a variety of human malignancies. The RhoGAP activity is required...