Duncan Penfold-Brown
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Explore the profile of Duncan Penfold-Brown including associated specialties, affiliations and a list of published articles.
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4
Citations
891
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Recent Articles
1.
Jiang Y, Ronnen Oron T, Clark W, Bankapur A, DAndrea D, Lepore R, et al.
Genome Biol
. 2016 Sep;
17(1):184.
PMID: 27604469
Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins,...
2.
Youngs N, Penfold-Brown D, Bonneau R, Shasha D
PLoS Comput Biol
. 2014 Jun;
10(6):e1003644.
PMID: 24922051
Negative examples - genes that are known not to carry out a given protein function - are rarely recorded in genome and proteome annotation databases, such as the Gene Ontology...
3.
Youngs N, Penfold-Brown D, Drew K, Shasha D, Bonneau R
Bioinformatics
. 2013 Mar;
29(9):1190-8.
PMID: 23511543
Motivation: Computational biologists have demonstrated the utility of using machine learning methods to predict protein function from an integration of multiple genome-wide data types. Yet, even the best performing function...
4.
Baltz A, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y, Schueler M, et al.
Mol Cell
. 2012 Jun;
46(5):674-90.
PMID: 22681889
Protein-RNA interactions are fundamental to core biological processes, such as mRNA splicing, localization, degradation, and translation. We developed a photoreactive nucleotide-enhanced UV crosslinking and oligo(dT) purification approach to identify the...