Kevin Drew
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Explore the profile of Kevin Drew including associated specialties, affiliations and a list of published articles.
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36
Citations
2025
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Recent Articles
1.
Balu S, Huget S, Medina Reyes J, Ragueneau E, Panneerselvam K, Fischer S, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D644-D650.
PMID: 39558156
The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated reference database for molecular complexes. It is a unifying web resource linking aggregated data on composition, topology and the function of macromolecular...
2.
Fischer S, Claussen E, Kourtis S, Sdelci S, Orchard S, Hermjakob H, et al.
bioRxiv
. 2024 Oct;
PMID: 39464102
Macromolecular protein complexes carry out most functions in the cell including essential functions required for cell survival. Unfortunately, we lack the subunit composition for all human protein complexes. To address...
3.
Fredrick A, Claussen E, Fischer S, Balasanyants S, Rajaraman A, Rosner A, et al.
MicroPubl Biol
. 2024 Jul;
2024.
PMID: 38947246
Mutations in retinal primary cilia are responsible for human blindness but the mechanisms are not fully understood (Wheway et al., 2014). Characterizing the proteome of an organelle such as cilia,...
4.
Cox R, Papoulas O, Shril S, Lee C, Gardner T, Battenhouse A, et al.
bioRxiv
. 2024 Jun;
PMID: 38853926
All eukaryotes share a common ancestor from roughly 1.5 - 1.8 billion years ago, a single-celled, swimming microbe known as LECA, the Last Eukaryotic Common Ancestor. Nearly half of the...
5.
Sepehri B, Drew K, Villegas J
Cell Chem Biol
. 2023 Nov;
30(11):1337-1339.
PMID: 37977129
Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for intracellular distribution. Kilgore et al. have examined small...
6.
Claussen E, Renfrew P, Muller C, Drew K
Proteins
. 2023 Oct;
92(3):343-355.
PMID: 37874196
The design of protein interaction inhibitors is a promising approach to address aberrant protein interactions that cause disease. One strategy in designing inhibitors is to use peptidomimetic scaffolds that mimic...
7.
Sae-Lee W, McCafferty C, Verbeke E, Havugimana P, Papoulas O, McWhite C, et al.
Cell Rep
. 2022 Jul;
40(3):111103.
PMID: 35858567
Red blood cells (RBCs) (erythrocytes) are the simplest primary human cells, lacking nuclei and major organelles and instead employing about a thousand proteins to dynamically control cellular function and morphology...
8.
Drew K, Wallingford J, Marcotte E
Mol Syst Biol
. 2021 May;
17(5):e10016.
PMID: 33973408
A general principle of biology is the self-assembly of proteins into functional complexes. Characterizing their composition is, therefore, required for our understanding of cellular functions. Unfortunately, we lack knowledge of...
9.
McWhite C, Papoulas O, Drew K, Dang V, Leggere J, Sae-Lee W, et al.
STAR Protoc
. 2021 Mar;
2(1):100370.
PMID: 33748783
Co-fractionation/mass spectrometry (CF/MS) is a flexible and powerful method to detect physical associations of proteins. CF/MS can be applied to any tissue or organism without the need for protein-specific antibodies...
10.
Floyd B, Drew K, Marcotte E
J Proteome Res
. 2021 Jan;
20(2):1359-1370.
PMID: 33476154
Protein phosphorylation is a key regulatory mechanism involved in nearly every eukaryotic cellular process. Increasingly sensitive mass spectrometry approaches have identified hundreds of thousands of phosphorylation sites, but the functions...