Duanchen Sun
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Explore the profile of Duanchen Sun including associated specialties, affiliations and a list of published articles.
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23
Citations
685
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Recent Articles
1.
Yu J, Leng J, Yuan F, Sun D, Wu L
Bioinformatics
. 2024 Jul;
40(7).
PMID: 38963312
Motivation: Gene regulatory networks (GRNs) are vital tools for delineating regulatory relationships between transcription factors and their target genes. The boom in computational biology and various biotechnologies has made inferring...
2.
Wu Q, Li Y, Wang Q, Zhao X, Sun D, Liu B
Front Genet
. 2024 Jul;
15:1424085.
PMID: 38952710
Motivation: The interaction between DNA motifs (DNA motif pairs) influences gene expression through partnership or competition in the process of gene regulation. Potential chromatin interactions between different DNA motifs have...
3.
Yu J, Leng J, Hou Z, Sun D, Wu L
Brief Bioinform
. 2024 Mar;
25(2).
PMID: 38493346
Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) data provided new insights into the understanding of epigenetic heterogeneity and transcriptional regulation. With the increasing abundance of dataset resources, there is...
4.
Wang C, Xu S, Sun D, Liu Z
Bioinformatics
. 2023 Sep;
39(9).
PMID: 37698984
Motivation: Protein-protein interactions (PPI) are crucial components of the biomolecular networks that enable cells to function. Biological experiments have identified a large number of PPI, and these interactions are stored...
5.
Thieme E, Bruss N, Sun D, Dominguez E, Coleman D, Liu T, et al.
Mol Cancer
. 2023 Mar;
22(1):64.
PMID: 36998071
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of cyclin-dependent kinases (CDK) demonstrated pre-clinical activity in...
6.
Westbrook T, Guan X, Rodansky E, Flores D, Liu C, Udager A, et al.
Nat Commun
. 2022 Sep;
13(1):5345.
PMID: 36109521
The androgen receptor (AR) signaling inhibitor enzalutamide (enza) is one of the principal treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent enza clinical resistance mechanisms have been described, including...
7.
Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts C, Sun D, et al.
Cancer Discov
. 2022 Jul;
12(10):2414-2433.
PMID: 35894778
Significance: Prior studies demonstrate the important moonlighting functions of metabolic enzymes in cancer. We find that the mitochondrial transaminase GOT2 binds directly to fatty acid ligands that regulate the nuclear...
8.
Guo Q, Sun D, Barrett A, Jindal S, Pennock N, Conklin M, et al.
Matrix Biol
. 2021 Nov;
105:104-126.
PMID: 34839002
Mammographically-detected breast density impacts breast cancer risk and progression, and fibrillar collagen is a key component of breast density. However, physiologic factors influencing collagen production in the breast are poorly...
9.
Sun D, Guan X, Moran A, Wu L, Qian D, Schedin P, et al.
Nat Biotechnol
. 2021 Nov;
40(4):527-538.
PMID: 34764492
Single-cell RNA sequencing (scRNA-seq) distinguishes cell types, states and lineages within the context of heterogeneous tissues. However, current single-cell data cannot directly link cell clusters with specific phenotypes. Here we...
10.
Jindal S, Pennock N, Sun D, Horton W, Ozaki M, Narasimhan J, et al.
Nat Commun
. 2021 Nov;
12(1):6341.
PMID: 34732713
Young women's breast cancer (YWBC) has poor prognosis and known interactions with parity. Women diagnosed within 5-10 years of childbirth, defined as postpartum breast cancer (PPBC), have poorer prognosis compared...