Douglas R Cavener
Overview
Explore the profile of Douglas R Cavener including associated specialties, affiliations and a list of published articles.
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57
Citations
4349
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Recent Articles
1.
Saraswat Ohri S, Forston M, Myers S, Brown B, Andres K, Howard R, et al.
Glia
. 2024 Apr;
72(7):1259-1272.
PMID: 38587137
After spinal cord injury (SCI), re-establishing cellular homeostasis is critical to optimize functional recovery. Central to that response is PERK signaling, which ultimately initiates a pro-apoptotic response if cellular homeostasis...
2.
Lohay G, Lee D, Wu-Cavener L, Pearce D, Hou X, Bond M, et al.
Ecol Evol
. 2023 Jun;
13(6):e10160.
PMID: 37313272
The Masai giraffe has experienced a population decline from 70,000 to 35,000 in the past three decades and was declared an endangered subspecies by the IUCN in 2019. The remaining...
3.
Hu J, Bourne R, McGrath B, Lin A, Pei Z, Cavener D
Mol Ther
. 2021 Apr;
29(11):3274-3292.
PMID: 33892188
With the development of CRISPR-Cas9-mediated gene-editing technologies, correction of disease-causing mutations has become possible. However, current gene-correction strategies preclude mutation repair in post-mitotic cells of human tissues, and a unique...
4.
Sidoli M, Reed C, Scapin C, Paez P, Cavener D, Kaufman R, et al.
J Neurosci
. 2021 Apr;
41(20):4536-4548.
PMID: 33879538
Schwann cells produce a considerable amount of lipids and proteins to form myelin in the PNS. For this reason, the quality control of myelin proteins is crucial to ensure proper...
5.
Lohay G, Weathers T, Estes A, McGrath B, Cavener D
Ecol Evol
. 2020 Nov;
10(20):11069-11089.
PMID: 33144949
Increasing human population growth, exurban development, and associated habitat fragmentation is accelerating the isolation of many natural areas and wildlife populations across the planet. In Tanzania, rapid and ongoing habitat...
6.
Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, et al.
PLoS Genet
. 2020 Apr;
16(4):e1008693.
PMID: 32324833
Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) restores homeostasis...
7.
Lee D, Cavener D, Bond M
PeerJ
. 2018 Oct;
6:e5690.
PMID: 30310743
Polymorphic phenotypes of mammalian coat coloration have been important to the study of genetics and evolution, but less is known about the inheritance and fitness consequences of individual variation in...
8.
Sowers C, Wang R, Bourne R, McGrath B, Hu J, Bevilacqua S, et al.
J Biol Chem
. 2018 Feb;
293(14):5134-5149.
PMID: 29444822
Loss-of-function mutations of the protein kinase PERK (EIF2AK3) in humans and mice cause permanent neonatal diabetes and severe proinsulin aggregation in the endoplasmic reticulum (ER), highlighting the essential role of...
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