Eric Klann
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Explore the profile of Eric Klann including associated specialties, affiliations and a list of published articles.
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165
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9872
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Recent Articles
1.
Nakatsuka N, Adler D, Jiang L, Hartman A, Cheng E, Klann E, et al.
bioRxiv
. 2024 Oct;
PMID: 39463993
We assessed the reproducibility of differentially expressed genes (DEGs) in previously published Alzheimer's (AD), Parkinson's (PD), Schizophrenia (SCZ), and COVID-19 scRNA-seq studies. While transcriptional scores from DEGs of individual PD...
2.
Tabaka O, Lawal S, Del Rio Triana R, Hou M, Fraser A, Gallagher A, et al.
bioRxiv
. 2024 Jul;
PMID: 38979197
Stress is a major risk for the onset of several maladaptive processes including pathological anxiety, a diffuse state of heightened apprehension over anticipated threats. Pathological anxiety is prevalent in up...
3.
Oliveira M, Mohamed M, Elder M, Banegas-Morales K, Mamcarz M, Lu E, et al.
Cell Rep
. 2024 Jan;
43(2):113670.
PMID: 38219147
Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to...
4.
Sharma V, Oliveira M, Sood R, Khlaifia A, Lou D, Hooshmandi M, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2308671120.
PMID: 38015848
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in...
5.
Castillo P, Jung H, Klann E, Riccio A
J Neurosci
. 2023 Nov;
43(45):7483-7488.
PMID: 37940588
Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of...
6.
Mohamed M, Klann E
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2307704120.
PMID: 37695913
Protein synthesis is a fundamental cellular process in neurons that is essential for synaptic plasticity and memory consolidation. Here, we describe our investigations of a neuron- and muscle-specific translation factor,...
7.
Alapin J, Mohamed M, Shrestha P, Khaled H, Vorabyeva A, Bowling H, et al.
bioRxiv
. 2023 Sep;
PMID: 37693507
The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is one of the primary triggers for initiating cap-dependent translation. Amongst its functions, mTORC1 phosphorylates eIF4E-binding proteins (4E-BPs), which prevents...
8.
Busch S, Simmons D, Gama E, Du X, Longo F, Gomez C, et al.
Front Cell Neurosci
. 2023 Aug;
17:1219270.
PMID: 37545882
, the gene encoding cytoplasmic FMR1 interacting protein 1, has been of interest as an autism candidate gene for years. A potential role in autism spectrum disorder (ASD) is suggested...
9.
Longo F, Aryal S, Anastasiades P, Maltese M, Baimel C, Albanese F, et al.
Cell Rep
. 2023 Jul;
42(8):112901.
PMID: 37505982
Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted and repetitive behaviors (RRBs). Consistent with observations in humans, FXS model...
10.
Shankar V, Klann E
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2309678120.
PMID: 37440569
No abstract available.