Barbara C McGrath
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Explore the profile of Barbara C McGrath including associated specialties, affiliations and a list of published articles.
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25
Citations
1954
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0
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Recent Articles
1.
Makova K, Pickett B, Harris R, Hartley G, Cechova M, Pal K, et al.
Nature
. 2024 May;
630(8016):401-411.
PMID: 38811727
Apes possess two sex chromosomes-the male-specific Y chromosome and the X chromosome, which is present in both males and females. The Y chromosome is crucial for male reproduction, with deletions...
2.
Makova K, Pickett B, Harris R, Hartley G, Cechova M, Pal K, et al.
bioRxiv
. 2023 Dec;
PMID: 38077089
Apes possess two sex chromosomes-the male-specific Y and the X shared by males and females. The Y chromosome is crucial for male reproduction, with deletions linked to infertility. The X...
3.
Hu J, Bourne R, McGrath B, Lin A, Pei Z, Cavener D
Mol Ther
. 2021 Apr;
29(11):3274-3292.
PMID: 33892188
With the development of CRISPR-Cas9-mediated gene-editing technologies, correction of disease-causing mutations has become possible. However, current gene-correction strategies preclude mutation repair in post-mitotic cells of human tissues, and a unique...
4.
Lohay G, Weathers T, Estes A, McGrath B, Cavener D
Ecol Evol
. 2020 Nov;
10(20):11069-11089.
PMID: 33144949
Increasing human population growth, exurban development, and associated habitat fragmentation is accelerating the isolation of many natural areas and wildlife populations across the planet. In Tanzania, rapid and ongoing habitat...
5.
Sowers C, Wang R, Bourne R, McGrath B, Hu J, Bevilacqua S, et al.
J Biol Chem
. 2018 Feb;
293(14):5134-5149.
PMID: 29444822
Loss-of-function mutations of the protein kinase PERK (EIF2AK3) in humans and mice cause permanent neonatal diabetes and severe proinsulin aggregation in the endoplasmic reticulum (ER), highlighting the essential role of...
6.
Zhu S, McGrath B, Bai Y, Tang X, Cavener D
Mol Brain
. 2016 Oct;
9(1):87.
PMID: 27716400
PERK (EIF2AK3) is an ER-resident eIF2α kinase required for behavioral flexibility and metabotropic glutamate receptor-dependent long-term depression via its translational control. Motivated by the recent discoveries that PERK regulates Ca...
7.
Zhu S, Henninger K, McGrath B, Cavener D
PLoS One
. 2016 Sep;
11(9):e0162766.
PMID: 27627766
PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's...
8.
Agaba M, Ishengoma E, Miller W, McGrath B, Hudson C, Bedoya Reina O, et al.
Nat Commun
. 2016 May;
7:11519.
PMID: 27187213
The origins of giraffe's imposing stature and associated cardiovascular adaptations are unknown. Okapi, which lacks these unique features, is giraffe's closest relative and provides a useful comparison, to identify genetic...
9.
Wang R, Munoz E, Zhu S, McGrath B, Cavener D
PLoS One
. 2014 Jun;
9(6):e99684.
PMID: 24915520
Background: Insulin synthesis and cell proliferation are under tight regulation in pancreatic β-cells to maintain glucose homeostasis. Dysfunction in either aspect leads to development of diabetes. PERK (EIF2AK3) loss of...
10.
Xu X, Hu J, McGrath B, Cavener D
PLoS One
. 2013 Oct;
8(10):e75917.
PMID: 24130751
The liver plays a central role in regulating lipid metabolism and facilitates efficient lipid utilization and storage. We discovered that a modest increase in maternal dietary fat in mice programs...