Christopher J Schwalen
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Explore the profile of Christopher J Schwalen including associated specialties, affiliations and a list of published articles.
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13
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1113
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Recent Articles
1.
Phulera S, Dickson C, Schwalen C, Khoshouei M, Cassell S, Sun Y, et al.
Structure
. 2024 Aug;
32(10):1611-1620.e4.
PMID: 39181123
Voltage-gated sodium (Nav) channels sense membrane potential and drive cellular electrical activity. The deathstalker scorpion α-toxin LqhαIT exerts a strong action potential prolonging effect on Nav channels. To elucidate the...
2.
Shukla R, Peoples A, Ludwig K, Maity S, Derks M, De Benedetti S, et al.
Cell
. 2023 Aug;
186(19):4059-4073.e27.
PMID: 37611581
Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant Gram-positive bacterial pathogens without...
3.
Shukla R, Peoples A, Ludwig K, Maity S, Derks M, De Benedetti S, et al.
bioRxiv
. 2023 Jun;
PMID: 37292624
Antimicrobial resistance is a leading mortality factor worldwide. Here we report the discovery of clovibactin, a new antibiotic, isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant bacterial pathogens without...
4.
Schwalen C, Babu C, Phulera S, Hao Q, Wall D, Nettleton D, et al.
ACS Omega
. 2021 Nov;
6(44):29555-29566.
PMID: 34778627
Knotted peptides present a wealth of structurally diverse, biologically active molecules, with the inhibitor cystine knot/knottin class among the most ecologically common ones. Many of these natural products interact with...
5.
Hudson G, Burkhart B, DiCaprio A, Schwalen C, Kille B, Pogorelov T, et al.
J Am Chem Soc
. 2021 Jul;
143(27):10479.
PMID: 34197098
No abstract available.
6.
Hudson G, Burkhart B, DiCaprio A, Schwalen C, Kille B, Pogorelov T, et al.
J Am Chem Soc
. 2019 May;
141(20):8228-8238.
PMID: 31059252
Recently developed bioinformatic tools have bolstered the discovery of ribosomally synthesized and post-translationally modified peptides (RiPPs). Using an improved version of Rapid ORF Description and Evaluation Online (RODEO 2.0), a...
7.
Hegemann J, Schwalen C, Mitchell D, van der Donk W
Chem Commun (Camb)
. 2018 Jul;
54(65):9007-9010.
PMID: 30046789
Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate...
8.
Schwalen C, Hudson G, Kille B, Mitchell D
J Am Chem Soc
. 2018 Jul;
140(30):9494-9501.
PMID: 29983054
Thiopeptides are members of the ribosomally synthesized and post-translationally modified peptide family of natural products. Most characterized thiopeptides display nanomolar potency toward Gram-positive bacteria by blocking protein translation with several...
9.
Schwalen C, Hudson G, Kosol S, Mahanta N, Challis G, Mitchell D
J Am Chem Soc
. 2017 Dec;
139(50):18154-18157.
PMID: 29200283
The bottromycins belong to the ribosomally synthesized and posttranslationally modified peptide (RiPP) family of natural products. Bottromycins exhibit unique structural features, including a hallmark macrolactamidine ring and thiazole heterocycle for...
10.
Blin K, Wolf T, Chevrette M, Lu X, Schwalen C, Kautsar S, et al.
Nucleic Acids Res
. 2017 May;
45(W1):W36-W41.
PMID: 28460038
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives originate from molecules produced by bacteria, fungi or plants. In recent years, genome mining methodologies have been widely adopted to identify...