Douglas A Mitchell
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Explore the profile of Douglas A Mitchell including associated specialties, affiliations and a list of published articles.
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128
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5768
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Recent Articles
11.
Harris L, Saad H, Shelton K, Zhu L, Guo X, Mitchell D
Biochemistry
. 2024 Mar;
63(7):865-879.
PMID: 38498885
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) defined by a macrolactam linkage between the N-terminus and the side chain of an internal aspartic acid...
12.
Clark J, Mi X, Mitchell D, Shukla D
ArXiv
. 2024 Mar;
PMID: 38463513
Ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic enzymes often exhibit promiscuous substrate preferences that cannot be reduced to simple rules. Large language models are promising tools for predicting such...
13.
Lee A, Carter R, Imani A, Dommaraju S, Hudson G, Mitchell D, et al.
bioRxiv
. 2024 Jan;
PMID: 38260703
Borosins are ribosomally synthesized and post-translationally modified peptides containing backbone α- -methylations. Identification of borosin precursor peptides is difficult because (1) there are no conserved sequence elements among borosin precursor...
14.
Fernandez H, Kretsch A, Kunakom S, Kadjo A, Mitchell D, Eustaquio A
ACS Synth Biol
. 2024 Jan;
13(1):337-350.
PMID: 38194362
The knotted configuration of lasso peptides confers thermal stability and proteolytic resistance, addressing two shortcomings of peptide-based drugs. However, low isolation yields hinder the discovery and development of lasso peptides....
15.
Woodard A, Peccati F, Navo C, Jimenez-Oses G, Mitchell D
bioRxiv
. 2023 Dec;
PMID: 38076856
The Gram-negative selective antibiotic darobactin A has attracted interest owing to its intriguing fused bicyclic structure and unique mode of action. Biosynthetic studies have revealed that darobactin is a ribosomally...
16.
Saad H, Majer T, Bhattarai K, Lampe S, Nguyen D, Kramer M, et al.
Chem Sci
. 2023 Nov;
14(45):13176-13183.
PMID: 38023510
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that feature an isopeptide bond and a distinct lariat fold. A growing number of secondary modifications have...
17.
Nguyen D, Zhu L, Gray D, Woods T, Padhi C, Flatt K, et al.
bioRxiv
. 2023 Nov;
PMID: 37965205
Advances in genome sequencing and bioinformatics methods have identified a myriad of biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining genomes for BGCs containing a prevalent peptide-binding domain used...
18.
Ren H, Huang C, Pan Y, Cui H, Dommaraju S, Mitchell D, et al.
bioRxiv
. 2023 Nov;
PMID: 37961664
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries . However, RiPPs are rarely reported as hybrid molecules...
19.
Precord T, Ramesh S, Dommaraju S, Harris L, Kille B, Mitchell D
ACS Bio Med Chem Au
. 2023 Jun;
3(3):240-251.
PMID: 37363077
The radical -adenosylmethionine (rSAM) superfamily has become a wellspring for discovering new enzyme chemistry, especially regarding ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we report a compendium of nearly...
20.
Chadwick G, Joiner A, Ramesh S, Mitchell D, Nayak D
Proc Natl Acad Sci U S A
. 2023 Jun;
120(25):e2302815120.
PMID: 37307484
Methyl-coenzyme M reductase (MCR) catalyzes the formation of methane, and its activity accounts for nearly all biologically produced methane released into the atmosphere. The assembly of MCR is an intricate...