Joel O Melby
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Explore the profile of Joel O Melby including associated specialties, affiliations and a list of published articles.
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12
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415
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Recent Articles
1.
Hadi T, Nozzi N, Melby J, Gao W, Fuerst D, Kvam E
Sci Rep
. 2020 Jun;
10(1):10279.
PMID: 32581345
The ability to quickly and easily assess the activity of large collections of enzymes for a desired substrate holds great promise in the field of biocatalysis. Cell-free synthesis, although not...
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3.
Metelev M, Tietz J, Melby J, Blair P, Zhu L, Livnat I, et al.
Chem Biol
. 2015 Jan;
22(2):241-50.
PMID: 25601074
Natural products are the most historically significant source of compounds for drug development. However, unacceptably high rates of compound rediscovery associated with large-scale screening of common microbial producers have resulted...
4.
Zhang Q, Ortega M, Shi Y, Wang H, Melby J, Tang W, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(33):12031-6.
PMID: 25092299
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a growing class of natural products that are found in all domains of life. These compounds possess vast structural diversity and have...
5.
Cox C, Tietz J, Sokolowski K, Melby J, Doroghazi J, Mitchell D
ACS Chem Biol
. 2014 Jun;
9(9):2014-22.
PMID: 24937678
Natural products remain an important source of drug candidates, but the difficulties inherent to traditional isolation, coupled with unacceptably high rates of compound rediscovery, limit the pace of natural product...
6.
Melby J, Li X, Mitchell D
Biochemistry
. 2013 Dec;
53(2):413-22.
PMID: 24364559
Thiazole/oxazole-modified microcins (TOMMs) comprise a structurally diverse family of natural products with varied bioactivities linked by the presence of posttranslationally installed thiazol(in)e and oxazol(in)e heterocycles. The detailed investigation of the...
7.
Lee J, Hao Y, Blair P, Melby J, Agarwal V, Burkhart B, et al.
Proc Natl Acad Sci U S A
. 2013 Jul;
110(32):12954-9.
PMID: 23878226
Plantazolicin (PZN), a polyheterocyclic, N(α),N(α)-dimethylarginine-containing antibiotic, harbors remarkably specific bactericidal activity toward strains of Bacillus anthracis, the causative agent of anthrax. Previous studies demonstrated that genetic deletion of the S-adenosyl-L-methionine-dependent...
8.
Deane C, Melby J, Molohon K, Susarrey A, Mitchell D
ACS Chem Biol
. 2013 Jul;
8(9):1998-2008.
PMID: 23823732
Plantazolicin (PZN) is a polyheterocyclic natural product derived from a ribosomal peptide that harbors remarkable antibiotic selectivity for the causative agent of anthrax, Bacillus anthracis. To simultaneously establish the structure-activity...
9.
Dunbar K, Melby J, Mitchell D
Nat Chem Biol
. 2012 Apr;
8(6):569-75.
PMID: 22522320
Thiazole/oxazole-modified microcins (TOMMs) encompass a recently defined class of ribosomally synthesized natural products with a diverse set of biological activities. Although TOMM biosynthesis has been investigated for over a decade,...
10.
Melby J, Dunbar K, Trinh N, Mitchell D
J Am Chem Soc
. 2012 Mar;
134(11):5309-16.
PMID: 22401305
The thiazole/oxazole-modified microcins (TOMMs) represent a burgeoning class of ribosomal natural products decorated with thiazoles and (methyl)oxazoles originating from cysteines, serines, and threonines. The ribosomal nature of TOMMs allows for...