Doreen Dobritzsch
Overview
Explore the profile of Doreen Dobritzsch including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
62
Citations
786
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Ge C, Tong D, Lonnblom E, Liang B, Cai W, Fahlquist-Hagert C, et al.
Arthritis Rheumatol
. 2022 Jan;
74(6):961-971.
PMID: 35080151
Objective: Cartilage oligomeric matrix protein (COMP) is an autoantigen in rheumatoid arthritis (RA) and experimental models of arthritis. This study was undertaken to investigate the structure, function, and relevance of...
12.
Ge C, Weisse S, Xu B, Dobritzsch D, Viljanen J, Kihlberg J, et al.
Ann Rheum Dis
. 2022 Jan;
81(4):480-489.
PMID: 35027402
Objectives: Rheumatoid arthritis (RA) is an autoimmune disease strongly associated with the major histocompatibility complex (MHC) class II allele DRB1*04:01, which encodes a protein that binds self-peptides for presentation to...
13.
Lenherr N, Christodoulou J, Duley J, Dobritzsch D, Fairbanks L, Datta A, et al.
Mol Genet Metab Rep
. 2021 Feb;
26:100709.
PMID: 33532242
Arts syndrome or phosphoribosyl-pyrophosphate-synthetase-1 (PRPS1) deficiency is caused by loss-of-function mutations in the gene (Xq22.3). PRPS1 is an initial and essential step for the synthesis of the nucleotides of purines,...
14.
Talibov V, Fabini E, FitzGerald E, Tedesco D, Cederfeldt D, Talu M, et al.
Chembiochem
. 2021 Jan;
22(9):1597-1608.
PMID: 33400854
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool...
15.
Puusepp S, Reinson K, Pajusalu S, van Kuilenburg A, Dobritzsch D, Roelofsen J, et al.
Mol Genet Metab Rep
. 2020 Dec;
25:100677.
PMID: 33294372
The gene, located on Xq22.3, encodes phosphoribosyl-pyrophosphate synthetase (PRPS), a key enzyme in de novo purine synthesis. Three clinical phenotypes are associated with loss-of-function variants and decreased PRPS activity: Arts...
16.
Yang J, Talibov V, Peintner S, Rhee C, Poongavanam V, Geitmann M, et al.
ACS Omega
. 2020 Mar;
5(8):3979-3995.
PMID: 32149225
Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme which regulates the methylation of Lys4 of histone 3 (H3) and is overexpressed in certain cancers. We used structures of H3 substrate...
17.
van Kuilenburg A, Tarailo-Graovac M, Richmond P, Drogemoller B, Pouladi M, Leen R, et al.
N Engl J Med
. 2019 Apr;
380(15):1433-1441.
PMID: 30970188
We report an inborn error of metabolism caused by an expansion of a GCA-repeat tract in the 5' untranslated region of the gene encoding glutaminase () that was identified through...
18.
Ge C, Xu B, Liang B, Lonnblom E, Lundstrom S, Zubarev R, et al.
Arthritis Rheumatol
. 2018 Aug;
71(2):210-221.
PMID: 30152126
Objective: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross-reactivity...
19.
Hampel S, Steitz J, Baierl A, Lehwald P, Wiesli L, Richter M, et al.
Chembiochem
. 2018 Aug;
19(21):2283-2292.
PMID: 30101542
A wide range of thiamine diphosphate (ThDP)-dependent enzymes catalyze the benzoin-type carboligation of pyruvate with aldehydes. A few ThDP-dependent enzymes, such as YerE from Yersinia pseudotuberculosis (YpYerE), are known to...
20.
Maurer D, Lohkamp B, Krumpel M, Widersten M, Dobritzsch D
Biochem J
. 2018 Jul;
475(14):2395-2416.
PMID: 29976570
β-Ureidopropionase (βUP) catalyzes the third step of the reductive pyrimidine catabolic pathway responsible for breakdown of uracil-, thymine- and pyrimidine-based antimetabolites such as 5-fluorouracil. Nitrilase-like βUPs use a tetrad of...