Dongwei Kang
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Explore the profile of Dongwei Kang including associated specialties, affiliations and a list of published articles.
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153
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1219
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Recent Articles
11.
Zhou Z, Liu X, Kang D
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000520
A vast and painful price has been paid in the battle against viruses in global health [...].
12.
Kang D
Environ Sci Pollut Res Int
. 2024 Jun;
31(31):43583-43590.
PMID: 38922472
The Sichuan takin (Budorcas tibetanus) and the golden takin (Budorcas bedfordi) are endemic to China. Studies of their habitat ecology have attracted attention, but dedicated reviews of the topic have...
13.
Jiang L, Liu N, Zhao F, Huang B, Kang D, Zhan P, et al.
Acta Pharm Sin B
. 2024 May;
14(5):1987-2005.
PMID: 38799621
The -methyl-d-aspartate (NMDA) receptors, which belong to the ionotropic Glutamate receptors, constitute a family of ligand-gated ion channels. Within the various subtypes of NMDA receptors, the GluN1/2A subtype plays a...
14.
Sun Y, Zhou Z, Wang N, Zhao F, Liu Y, Xu X, et al.
J Med Chem
. 2024 Apr;
67(8):6570-6584.
PMID: 38613773
NNRTI is an important component of the highly active antiretroviral therapy (HAART), but the rapid emergence of drug resistance and poor pharmacokinetics limited their clinical application. Herein, a series of...
15.
Sang Z, Zhang T, Wang Z, De Clercq E, Pannecouque C, Kang D, et al.
Chem Biol Drug Des
. 2024 Mar;
103(3):e14510.
PMID: 38519265
In this study, a novel series of diarylpyrimidine derivatives with Fsp-enriched spirocycles were designed and synthesized to further explore the chemical space of the hydrophobic channel of the NNRTI-binding pocket....
16.
Wang Z, Zhang H, Gao Z, Sang Z, De Clercq E, Pannecouque C, et al.
Acta Pharm Sin B
. 2024 Mar;
14(3):1257-1282.
PMID: 38486991
With our continuous endeavors in seeking potent anti-HIV-1 agents, we reported here the discovery, biological characterization, and druggability evaluation of a class of nonnucleoside reverse transcriptase inhibitors. To fully explore...
17.
Xie M, Wang Z, Zhao F, Li Y, Zhuo Z, Li X, et al.
J Med Virol
. 2024 Mar;
96(3):e29502.
PMID: 38450817
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important component of anti-acquired immunodeficiency syndrome treatment regimen. In the present work, with the previously reported compound K-16c as lead, a series of...
18.
Zhou Z, Zhang W, Zhao F, Sun Y, Wang N, Cheng J, et al.
J Med Chem
. 2024 Feb;
67(5):4234-4249.
PMID: 38416116
The existing available antipsychotics have failed to manage the cognitive impairment of schizophrenia and induced a number of seriously undesirable effects. Trace amine-associated receptor 1 (TAAR1) has emerged as an...
19.
Song L, Gao S, Ye B, Yang M, Cheng Y, Kang D, et al.
Acta Pharm Sin B
. 2024 Jan;
14(1):87-109.
PMID: 38239241
No abstract available.
20.
Sun Y, Feng D, Zhou Z, Zhang T, De Clercq E, Pannecouque C, et al.
Bioorg Med Chem
. 2023 Nov;
96:117484.
PMID: 37976805
HIV-1 reverse transcriptase (RT) is considered as one of the most significant targets for the anti-HIV-1 drug design due to their determined mechanism and well-decoded crystal structure. As a part...