Dongwei Kang
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Explore the profile of Dongwei Kang including associated specialties, affiliations and a list of published articles.
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153
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1219
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Recent Articles
21.
Shang P, Rong N, Jiang J, Cheng J, Zhang M, Kang D, et al.
Cell
. 2023 Nov;
186(24):5347-5362.e24.
PMID: 37963465
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy....
22.
Wei W, Jing L, Tian Y, Wieckowska A, Kang D, Meng B, et al.
Bioorg Med Chem
. 2023 Nov;
96:117535.
PMID: 37956505
As Alzheimer's disease (AD) is a neurodegenerative disease with a complex pathogenesis, the exploration of multi-target drugs may be an effective strategy for AD treatment. Multifunctional small molecular agents can...
23.
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, et al.
Nat Commun
. 2023 Aug;
14(1):5004.
PMID: 37591889
MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures...
24.
Song H, Xia Y, Zhang T, Dun C, Meng B, De Clercq E, et al.
Eur J Med Chem
. 2023 Aug;
259:115686.
PMID: 37536208
To develop more potent HIV-1 inhibitors against a variety of NNRTIs-resistant strains, a series of 5-cyano substituted diarylpyridines was designed based on the cocrystal structural analysis. Among them, I-5b showed...
25.
Gao M, Kang D, Liu N, Liu Y
Molecules
. 2023 Jul;
28(14).
PMID: 37513194
The COVID-19 pandemic has caused severe health threat globally, and novel SARS-Cov-2 inhibitors are urgently needed for antiviral treatment. The main protease (M) of the virus is one of the...
26.
Li P, Ju H, Zhang Y, Achi J, Kang D, Zou J, et al.
J Med Virol
. 2023 Jul;
95(7):e28968.
PMID: 37489704
Influenza viruses pose a significant threat to human health worldwide due to seasonal epidemics and occasional global pandemics. These viruses can cause severe upper respiratory tract infections that contribute to...
27.
Zhang X, Sun L, Xu S, Huang T, Zhao F, Ding D, et al.
RSC Med Chem
. 2023 Jul;
14(7):1272-1295.
PMID: 37484571
HIV-1 capsid (CA) is an attractive target for its indispensable roles in the viral life cycle. We report the design, synthesis, and mechanistic study of a novel series of 2-piperazineone...
28.
Gao S, Song L, Cheng Y, Zhao F, Kang D, Song S, et al.
Acta Pharm Sin B
. 2023 Jul;
13(6):2747-2764.
PMID: 37425059
Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity To address the high cytotoxicity and improve safety profiles of IASs,...
29.
Jiang X, Huang B, Zalloum W, Chen C, Ji X, Gao Z, et al.
Eur J Med Chem
. 2023 Jul;
258:115605.
PMID: 37393790
Taking our previously reported HIV-1 NNRTIs BH-11c and XJ-10c as lead compounds, series of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles were designed to improve anti-resistance and drug-like profiles. According...
30.
Wang Z, Sharma P, Rathi B, Xie M, De Clercq E, Pannecouque C, et al.
J Med Chem
. 2023 May;
66(13):8643-8665.
PMID: 37255025
In the current landscape of antiretroviral options, there remains an urgent need for novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) with improved resistance profiles and safety properties. Herein, a series of...