Donalyn Scheuner
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Explore the profile of Donalyn Scheuner including associated specialties, affiliations and a list of published articles.
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35
Citations
5600
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0
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Recent Articles
1.
Syed F, Ballew O, Lee C, Rana J, Krishnan P, Castela A, et al.
bioRxiv
. 2024 May;
PMID: 38766166
Tyrosine protein-kinase 2 (TYK2), a member of the Janus kinase family, mediates inflammatory signaling through multiple cytokines, including interferon-α (IFNα), interleukin (IL)-12, and IL-23. Missense mutations in TYK2 are associated...
2.
Anderson-Baucum E, Pineros A, Kulkarni A, Webb-Robertson B, Maier B, Anderson R, et al.
Cell Metab
. 2021 Sep;
33(9):1883-1893.e7.
PMID: 34496231
The metabolic inflammation (meta-inflammation) of obesity is characterized by proinflammatory macrophage infiltration into adipose tissue. Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp)...
3.
Frabutt D, Stull N, Pineros A, Tersey S, Scheuner D, Mastracci T, et al.
Arch Autoimmune Dis
. 2021 Aug;
1(1):3-13.
PMID: 34414399
The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis...
4.
Kalwat M, Scheuner D, Rodrigues-Dos-Santos K, Eizirik D, Cobb M
Endocrinology
. 2021 Aug;
162(11).
PMID: 34407177
Pancreatic β cells dedicate much of their protein translation capacity to producing insulin to maintain glucose homeostasis. In response to increased secretory demand, β cells can compensate by increasing insulin...
5.
Templin A, Meier D, Willard J, Wolden-Hanson T, Conway K, Lin Y, et al.
Diabetologia
. 2018 Jul;
61(10):2215-2224.
PMID: 30046852
Aims/hypothesis: Islet amyloid deposits contribute to beta cell dysfunction and death in most individuals with type 2 diabetes but non-invasive methods to determine the presence of these pathological protein aggregates...
6.
Chen Y, Song M, Riley J, Hu C, Peng X, Scheuner D, et al.
Pharmacol Res Perspect
. 2017 Jan;
4(6):e00278.
PMID: 28097011
LY2881835 is a selective, potent, and efficacious GPR40 agonist. The objective of the studies described here was to examine the pharmacological properties of LY2881835 in preclinical models of T2D. Significant...
7.
Muaddi H, Majumder M, Peidis P, Papadakis A, Holcik M, Scheuner D, et al.
Mol Biol Cell
. 2010 Jul;
21(18):3220-31.
PMID: 20660158
Various forms of stress induce pathways that converge on the phosphorylation of the alpha (α) subunit of eukaryotic translation initiation factor eIF2 at serine 51 (S51), a modification that results...
8.
Schulz O, Pichlmair A, Rehwinkel J, Rogers N, Scheuner D, Kato H, et al.
Cell Host Microbe
. 2010 May;
7(5):354-61.
PMID: 20478537
Cytosolic viral RNA recognition by the helicases RIG-I and MDA5 is considered the major pathway for IFN-alpha/beta induction in response to RNA viruses. However, other cytoplasmic RNA sensors, including the...
9.
Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan C, Wang C, et al.
J Biol Chem
. 2010 Mar;
285(22):17098-111.
PMID: 20338999
Regulation of cell volume is of great importance because persistent swelling or shrinkage leads to cell death. Tissues experience hypertonicity in both physiological (kidney medullar cells) and pathological states (hypernatremia)....
10.
Mounir Z, Krishnamoorthy J, Robertson G, Scheuner D, Kaufman R, Georgescu M, et al.
Sci Signal
. 2009 Dec;
2(102):ra85.
PMID: 20029030
Inhibition of protein synthesis by phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2) at Ser(51) occurs as a result of the activation of a family of...