Donalyn Scheuner
Overview
Explore the profile of Donalyn Scheuner including associated specialties, affiliations and a list of published articles.
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35
Citations
5600
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Recent Articles
11.
Back S, Scheuner D, Han J, Song B, Ribick M, Wang J, et al.
Cell Metab
. 2009 Jul;
10(1):13-26.
PMID: 19583950
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on Ser51 of the alpha subunit (eIF2alpha). To elucidate the...
12.
DuRose J, Scheuner D, Kaufman R, Rothblum L, Niwa M
Mol Cell Biol
. 2009 May;
29(15):4295-307.
PMID: 19470760
The endoplasmic reticulum (ER) is the major cellular compartment where folding and maturation of secretory and membrane proteins take place. When protein folding needs exceed the capacity of the ER,...
13.
Harding H, Zhang Y, Scheuner D, Chen J, Kaufman R, Ron D
Proc Natl Acad Sci U S A
. 2009 Feb;
106(6):1832-7.
PMID: 19181853
Diverse cellular stress responses are linked to phosphorylation of serine 51 on the alpha subunit of translation initiation factor 2. The resultant attenuation of protein synthesis and activation of gene...
14.
Song B, Scheuner D, Ron D, Pennathur S, Kaufman R
J Clin Invest
. 2008 Sep;
118(10):3378-89.
PMID: 18776938
The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic beta cells to produce sufficient levels of insulin to meet the metabolic demand. Recent...
15.
Mak B, Wang Q, Laschinger C, Lee W, Ron D, Harding H, et al.
J Biol Chem
. 2008 Jun;
283(34):23462-72.
PMID: 18550523
Induction of apoptosis by tensile forces is an important determinant of connective tissue destruction in osteoarthritis and periodontal diseases. We examined the role of molecular components of the unfolded protein...
16.
Scheuner D, Kaufman R
Endocr Rev
. 2008 Apr;
29(3):317-33.
PMID: 18436705
The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized proteins destined for the cell surface or released into the extracellular milieu. The study of...
17.
Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, et al.
Endocrinology
. 2006 Nov;
148(2):609-17.
PMID: 17082262
Both the rate of overall translation and the specific acceleration of proinsulin synthesis are known to be glucose-regulated processes in the beta-cell. In this study, we propose that glucose-induced stimulation...
18.
Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, et al.
J Biol Chem
. 2006 May;
281(30):21458-21468.
PMID: 16717090
As the molecular processes of complex cell stress signaling pathways are defined, the subsequent challenge is to elucidate how each individual event influences the final biological outcome. Phosphorylation of the...
19.
Harding H, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman R, et al.
Cell Metab
. 2005 Dec;
2(6):361-71.
PMID: 16330322
Phosphorylation of translation initiation factor 2alpha (eIF2alpha) coordinates a translational and transcriptional program known as the integrated stress response (ISR), which adapts cells to endoplasmic reticulum (ER) stress. A screen...
20.
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, et al.
EMBO J
. 2005 Sep;
24(19):3470-81.
PMID: 16148948
Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression. While much emphasis has been placed on the role of HIF-1 in this context, the role of...