Dmitry Velmeshev
Overview
Explore the profile of Dmitry Velmeshev including associated specialties, affiliations and a list of published articles.
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35
Citations
2097
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Recent Articles
1.
Xu J, Yan Z, Bang S, Velmeshev D, Ji R
Neuron
. 2025 Feb;
PMID: 39952243
Astrocytes in the spinal cord dorsal horn (SDH) play a pivotal role in synaptic transmission and neuropathic pain. However, the precise classification of SDH astrocytes in health and disease remains...
2.
Gao Y, Shonai D, Trn M, Zhao J, Soderblom E, Garcia-Moreno S, et al.
Nat Commun
. 2024 Aug;
15(1):6801.
PMID: 39122707
One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable...
3.
Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, et al.
Mol Neurodegener
. 2024 Jun;
19(1):47.
PMID: 38862989
Background: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types...
4.
Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, et al.
bioRxiv
. 2024 Apr;
PMID: 38659797
Background: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types...
5.
Velmeshev D, Perez Y, Yan Z, Valencia J, Castaneda-Castellanos D, Wang L, et al.
Science
. 2023 Oct;
382(6667):eadf0834.
PMID: 37824647
We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific programs that underlie the development of specific subtypes of excitatory cortical...
6.
Perez Y, Velmeshev D, Wang L, White M, Siebert C, Baltazar J, et al.
bioRxiv
. 2023 Oct;
PMID: 37790331
Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic homogeneity compared to idiopathic autism, dup15q syndrome provides...
7.
Marsan E, Velmeshev D, Ramsey A, Patel R, Zhang J, Koontz M, et al.
J Clin Invest
. 2023 Jan;
133(6).
PMID: 36602862
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in...
8.
Trobisch T, Zulji A, Stevens N, Schwarz S, Wischnewski S, Ozturk M, et al.
Acta Neuropathol
. 2022 Sep;
144(5):987-1003.
PMID: 36112223
Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central nervous system (CNS). However, the compartmentalized pathology of the disease affecting various anatomical regions including gray and...
9.
Andrews M, Mukhtar T, Eze U, Simoneau C, Ross J, Parikshak N, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2122236119.
PMID: 35858406
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with particularly severe impact on respiratory function. Neurological...
10.
Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo-Radji M, et al.
bioRxiv
. 2021 Jan;
PMID: 33469577
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with particularly severe impact on respiratory function. It...