Dmitry Velmeshev
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Explore the profile of Dmitry Velmeshev including associated specialties, affiliations and a list of published articles.
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35
Citations
2097
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Recent Articles
11.
Zhang J, Velmeshev D, Hashimoto K, Huang Y, Hofmann J, Shi X, et al.
Nature
. 2020 Sep;
588(7838):459-465.
PMID: 32866962
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsufficiency in the gene encoding progranulin. However, the mechanism leading to TDP-43...
12.
Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp C, et al.
Cell
. 2020 Jul;
182(3):594-608.e11.
PMID: 32679030
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential play important roles in human neurogenesis and gray matter expansion, the...
13.
Herrero M, Velmeshev D, Hernandez-Pineda D, Sethi S, Sorrells S, Banerjee P, et al.
Mol Autism
. 2020 May;
11(1):39.
PMID: 32460837
Background: Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification of hundreds of ASD susceptibility genes. ASD is characterized by social deficits...
14.
Velmeshev D, Magistri M, Mazza E, Lally P, Khoury N, DElia E, et al.
Mol Neurobiol
. 2020 Feb;
57(5):2279-2289.
PMID: 32008165
Despite its heterogeneity, autism is characterized by a defined behavioral phenotype, suggesting that the molecular pathology affects specific neural substrates to cause behavioral dysfunction. Previous studies identified genes dysregulated in...
15.
Bhaduri A, Di Lullo E, Jung D, Muller S, Crouch E, Espinosa C, et al.
Cell Stem Cell
. 2020 Jan;
26(1):48-63.e6.
PMID: 31901251
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell...
16.
Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, et al.
Nature
. 2019 Jul;
573(7772):75-82.
PMID: 31316211
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and neurodegeneration at chronic stages....
17.
Sorrells S, Paredes M, Velmeshev D, Herranz-Perez V, Sandoval K, Mayer S, et al.
Nat Commun
. 2019 Jun;
10(1):2748.
PMID: 31227709
The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a large population of immature neurons in the paralaminar nuclei (PL),...
18.
Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, et al.
Science
. 2019 May;
364(6441):685-689.
PMID: 31097668
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism patients converge on common genes and pathways. However, direct assessment...
19.
Mayer S, Chen J, Velmeshev D, Mayer A, Eze U, Bhaduri A, et al.
Neuron
. 2019 Feb;
102(1):143-158.e7.
PMID: 30770253
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters. While single-cell RNA sequencing has revealed cellular...
20.
Nowakowski T, Bhaduri A, Pollen A, Alvarado B, Mostajo-Radji M, Di Lullo E, et al.
Science
. 2017 Dec;
358(6368):1318-1323.
PMID: 29217575
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified...