Divya Ramnath
Overview
Explore the profile of Divya Ramnath including associated specialties, affiliations and a list of published articles.
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16
Citations
605
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Recent Articles
1.
Wang Y, Curson J, Ramnath D, Das Gupta K, Reid R, Karunakaran D, et al.
Biochem J
. 2024 Oct;
481(21):1569-1584.
PMID: 39373581
Histone deacetylase 7 (HDAC7) is a member of the class IIa family of classical HDACs with important roles in cell development, differentiation, and activation, including in macrophages and other innate...
2.
Sweet M, Ramnath D, Singhal A, Kapetanovic R
Nat Rev Immunol
. 2024 Sep;
25(2):92-107.
PMID: 39294278
Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled antimicrobial responses, such as the generation of reactive oxygen species and the delivery of hydrolytic enzymes from lysosomes to the phagosome. However,...
3.
Duszyc K, von Pein J, Ramnath D, Currin-Ross D, Verma S, Lim F, et al.
Dev Cell
. 2023 Aug;
58(21):2235-2248.e6.
PMID: 37647898
Apoptosis is traditionally considered to be an immunologically silent form of cell death. Multiple mechanisms exist to ensure that apoptosis does not stimulate the immune system to cause inflammation or...
4.
Das Gupta K, Ramnath D, von Pein J, Curson J, Wang Y, Abrol R, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2212813120.
PMID: 36649417
The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7...
5.
Wang Y, Abrol R, Mak J, Das Gupta K, Ramnath D, Karunakaran D, et al.
FEBS J
. 2022 Mar;
290(11):2805-2832.
PMID: 35303381
Histone deacetylases (HDACs) catalyse removal of acetyl groups from lysine residues on both histone and non-histone proteins to control numerous cellular processes. Of the 11 zinc-dependent classical HDACs, HDAC4, 5,...
6.
Jouffe C, Weger B, Martin E, Atger F, Weger M, Gobet C, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(10):e2200083119.
PMID: 35238641
SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described....
7.
Ramnath D, Das Gupta K, Wang Y, Abrol R, Curson J, Lim J, et al.
J Leukoc Biol
. 2021 Nov;
111(2):327-336.
PMID: 34811804
TLRs reprogram macrophage metabolism, enhancing glycolysis and promoting flux through the tricarboxylic acid cycle to enable histone acetylation and inflammatory gene expression. The histone deacetylase (HDAC) family of lysine deacetylases...
8.
Kapetanovic R, Afroz S, Ramnath D, Lawrence G, Okada T, Curson J, et al.
Immunol Cell Biol
. 2020 Jul;
98(7):528-539.
PMID: 32686869
Mitochondria have a multitude of functions, including energy generation and cell signaling. Recent evidence suggests that mitochondrial dynamics (i.e. the balance between mitochondrial fission and fusion) also regulate immune functions....
9.
Das Gupta K, Shakespear M, Curson J, Murthy A, Iyer A, Hodson M, et al.
Cell Rep
. 2020 Feb;
30(8):2712-2728.e8.
PMID: 32101747
Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A proteomic...
10.
Loh Z, Fitzsimmons R, Reid R, Ramnath D, Clouston A, Gupta P, et al.
Br J Pharmacol
. 2019 Jun;
176(19):3775-3790.
PMID: 31236923
Background And Purpose: Chronic liver diseases feature excessive collagen and matrix protein deposition or crosslinking that characterises fibrosis, leads to scar tissue, and disrupts liver functions. There is no effective...