Dirk C Hoffmann
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Explore the profile of Dirk C Hoffmann including associated specialties, affiliations and a list of published articles.
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17
Citations
416
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Recent Articles
1.
Cebulla G, Hai L, Warnken U, Gungor C, Hoffmann D, Korporal-Kuhnke M, et al.
J Neurol
. 2025 Mar;
272(4):270.
PMID: 40085221
Background: 5q-associated spinal muscular atrophy (SMA) is a monogenic disease causing progressive alpha motor neuron degeneration, muscle atrophy, and weakness. Intrathecal therapy with the antisense oligonucleotide nusinersen modifies the disease...
2.
Hai L, Friedel D, Hinz F, Hoffmann D, Doubrovinskaia S, Rohdjess H, et al.
Neuro Oncol
. 2024 Nov;
PMID: 39575767
Background: Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights...
3.
Kaulen L, Hielscher T, Doubrovinskaia S, Hoffmann D, Kessler T, Traub B, et al.
Neurology
. 2024 Aug;
103(4):e209698.
PMID: 39102613
Background And Objectives: Neurolymphomatosis (NL) refers to lymphomatous infiltration of the peripheral nervous system (PNS). NL diagnosis and treatment are challenging given the broad differential diagnosis of peripheral neuropathy, the...
4.
Schlieper-Scherf S, Hebach N, Hausmann D, Azorin D, Hoffmann D, Horschitz S, et al.
J Neurooncol
. 2024 Aug;
170(1):139-151.
PMID: 39088157
Purpose: This study investigates the biological effect of Tumor Treating Fields (TTFields) on key drivers of glioblastoma's malignancy-tumor microtube (TM) formation-and on the function and overall integrity of the tumor...
5.
Huppertz M, Wilhelm J, Grenier V, Schneider M, Falt T, Porzberg N, et al.
Science
. 2024 Feb;
383(6685):890-897.
PMID: 38386755
Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular...
6.
Hai L, Hoffmann D, Wagener R, Azorin D, Hausmann D, Xie R, et al.
Nat Commun
. 2024 Feb;
15(1):968.
PMID: 38320988
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the...
7.
Iser F, Hinz F, Hoffmann D, Grassl N, Gungoor C, Meyer J, et al.
Clin Cancer Res
. 2024 Jan;
30(14):2974-2985.
PMID: 38295147
Purpose: Primary central nervous system (CNS) gliomas can be classified by characteristic genetic alterations. In addition to solid tissue obtained via surgery or biopsy, cell-free DNA (cfDNA) from cerebrospinal fluid...
8.
Kramer C, Kilian M, Chih Y, Kourtesakis A, Hoffmann D, Boschert T, et al.
Neuro Oncol
. 2023 Sep;
26(2):266-278.
PMID: 37715782
Background: Neuroligin 4 X-linked (NLGN4X) harbors a human leukocyte antigen (HLA)-A*02-restricted tumor-associated antigen, overexpressed in human gliomas, that was found to induce specific cytotoxic T cell responses following multi-peptide vaccination...
9.
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, et al.
Acta Neuropathol
. 2023 Jul;
146(3):499-514.
PMID: 37495858
Immunodeficiency-associated primary CNS lymphoma (PCNSL) represents a distinct clinicopathological entity, which is typically Epstein-Barr virus-positive (EBV) and carries an inferior prognosis. Genetic alterations that characterize EBV-related CNS lymphomagenesis remain unclear...
10.
Ratliff M, Karimian-Jazi K, Hoffmann D, Rauschenbach L, Simon M, Hai L, et al.
Neuro Oncol
. 2023 Jun;
25(12):2150-2162.
PMID: 37335907
Background: Glioblastomas are characterized by aggressive and infiltrative growth, and by striking heterogeneity. The aim of this study was to investigate whether tumor cell proliferation and invasion are interrelated, or...