Dirk C Hoffmann
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Explore the profile of Dirk C Hoffmann including associated specialties, affiliations and a list of published articles.
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17
Citations
416
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Recent Articles
11.
Hausmann D, Hoffmann D, Venkataramani V, Jung E, Horschitz S, Tetzlaff S, et al.
Nature
. 2022 Dec;
613(7942):179-186.
PMID: 36517594
Diffuse gliomas, particularly glioblastomas, are incurable brain tumours. They are characterized by networks of interconnected brain tumour cells that communicate via Ca transients. However, the networks' architecture and communication strategy...
12.
Venkataramani V, Yang Y, Schubert M, Reyhan E, Tetzlaff S, Wissmann N, et al.
Cell
. 2022 Aug;
185(16):2899-2917.e31.
PMID: 35914528
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma cells forms a functional and therapy-resistant tumor cell network interconnected by tumor microtubes (TMs). Other subpopulations appear unconnected, and...
13.
Tang Z, Dokic I, Knoll M, Ciamarone F, Schwager C, Klein C, et al.
Int J Radiat Oncol Biol Phys
. 2021 Sep;
112(2):499-513.
PMID: 34534627
Purpose: Infiltrative growth pattern is a hallmark of glioblastoma (GBM). Radiation therapy aims to eradicate microscopic residual GBM cells after surgical removal of the visible tumor bulk. However, in-field recurrences...
14.
Tehranian C, Fankhauser L, Harter P, Ratcliffe C, Zeiner P, Messmer J, et al.
Neuro Oncol
. 2021 Jul;
24(2):213-225.
PMID: 34216217
Background: Brain metastases (BM) are a frequent complication of malignant melanoma (MM), with limited treatment options and poor survival. Prevention of BM could be more effective and better tolerated than...
15.
Schmid D, Warnken U, Latzer P, Hoffmann D, Roth J, Kutschmann S, et al.
J Neurochem
. 2021 Mar;
158(2):522-538.
PMID: 33735443
Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to repetitively monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue...
16.
Jung E, Osswald M, Ratliff M, Dogan H, Xie R, Weil S, et al.
Nat Commun
. 2021 Feb;
12(1):1014.
PMID: 33579922
Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution...
17.
Xie R, Kessler T, Grosch J, Hai L, Venkataramani V, Huang L, et al.
Neuro Oncol
. 2020 Dec;
23(5):757-769.
PMID: 33320195
Background: Malignant gliomas including glioblastomas are characterized by a striking cellular heterogeneity, which includes a subpopulation of glioma cells that becomes highly resistant by integration into tumor microtube (TM)-connected multicellular...
18.
Kessler T, Berberich A, Sadik A, Sahm F, Gorlia T, Meisner C, et al.
Cancer Med
. 2020 Sep;
9(22):8373-8385.
PMID: 32991787
Background: Gliomas evade current therapies through primary and acquired resistance and the effect of temozolomide is mainly restricted to methylguanin-O6-methyltransferase promoter (MGMT) promoter hypermethylated tumors. Further resistance markers are largely...